• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.Smc5-Smc6通过促进姐妹染色单体重组来介导DNA双链断裂修复。
Nat Cell Biol. 2006 Sep;8(9):1032-4. doi: 10.1038/ncb1466. Epub 2006 Aug 6.
2
Rtt107 phosphorylation promotes localisation to DNA double-stranded breaks (DSBs) and recombinational repair between sister chromatids.Rtt107 磷酸化促进定位到 DNA 双链断裂 (DSB) 以及姐妹染色单体之间的重组修复。
PLoS One. 2011;6(5):e20152. doi: 10.1371/journal.pone.0020152. Epub 2011 May 25.
3
Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels.在减数分裂过程中抑制 Smc5/6 复合物会干扰联会复合体的形成和解决，但不会显著改变交叉或非交叉水平。
PLoS Genet. 2013 Nov;9(11):e1003898. doi: 10.1371/journal.pgen.1003898. Epub 2013 Nov 7.
4
Regulation of rDNA stability by sumoylation.通过SUMO化修饰对核糖体DNA稳定性的调控。
DNA Repair (Amst). 2009 Apr 5;8(4):507-16. doi: 10.1016/j.dnarep.2009.01.015. Epub 2009 Mar 3.
5
Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid.组蛋白 H3K56 乙酰化、Rad52 和非 DNA 修复因子控制与姐妹染色单体的双链断裂修复选择。
PLoS Genet. 2013;9(1):e1003237. doi: 10.1371/journal.pgen.1003237. Epub 2013 Jan 24.
6
Saccharomyces cerevisiae RAD53 (CHK2) but not CHK1 is required for double-strand break-initiated SCE and DNA damage-associated SCE after exposure to X rays and chemical agents.酿酒酵母RAD53（CHK2）而非CHK1是暴露于X射线和化学试剂后双链断裂引发的姐妹染色单体交换（SCE）以及与DNA损伤相关的SCE所必需的。
DNA Repair (Amst). 2005 Nov 21;4(11):1240-51. doi: 10.1016/j.dnarep.2005.06.006. Epub 2005 Jul 21.
7
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae.在酿酒酵母中，Dot1组蛋白甲基转移酶和Rad9检查点衔接蛋白通过姐妹染色单体重组促进依赖黏连蛋白的双链断裂修复。
Genetics. 2009 Jun;182(2):437-46. doi: 10.1534/genetics.109.101899. Epub 2009 Mar 30.
8
SUMOylation of the α-kleisin subunit of cohesin is required for DNA damage-induced cohesion.SUMOylation of the α-kleisin subunit of cohesin is required for DNA damage-induced cohesion. 着丝粒蛋白复合体的α- kleisin 亚基的 SUMOylation 对于 DNA 损伤诱导的黏合是必需的。
Curr Biol. 2012 Sep 11;22(17):1564-75. doi: 10.1016/j.cub.2012.06.045. Epub 2012 Jul 5.
9
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast.酵母中通过姐妹染色单体重组对复制产生的双链断裂进行修复的分析。
Methods Enzymol. 2021;661:121-138. doi: 10.1016/bs.mie.2021.08.010. Epub 2021 Sep 21.
10
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.人类SMC5/6复合物通过将SMC1/3黏连蛋白复合物招募至双链断裂处来促进姐妹染色单体同源重组。
EMBO J. 2006 Jul 26;25(14):3377-88. doi: 10.1038/sj.emboj.7601218. Epub 2006 Jun 29.

引用本文的文献

1
Structural basis of the hepatitis B virus X protein in complex with DDB1.乙型肝炎病毒X蛋白与损伤特异性DNA结合蛋白1复合物的结构基础
Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2421325122. doi: 10.1073/pnas.2421325122. Epub 2025 Jun 13.
2
Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis.识别乳腺癌患者基因组中因爱泼斯坦-巴尔病毒感染而失效的保护机制：染色体生物信息学分析
JMIRx Med. 2025 Jan 29;6:e50712. doi: 10.2196/50712.
3
Cohesin complex oligomerization maintains end-tethering at DNA double-strand breaks.黏连蛋白复合体寡聚化维持DNA双链断裂处的末端连接。
Nat Cell Biol. 2025 Jan;27(1):118-129. doi: 10.1038/s41556-024-01552-2. Epub 2024 Oct 31.
4
Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork.在停滞的复制叉处 SLF1 与组蛋白 H4 和 RAD18 相互作用的结构机制。
Nucleic Acids Res. 2024 Nov 11;52(20):12405-12421. doi: 10.1093/nar/gkae831.
5
Multifaceted roles of SUMO in DNA metabolism.SUMO 在 DNA 代谢中的多方面作用。
Nucleus. 2024 Dec;15(1):2398450. doi: 10.1080/19491034.2024.2398450. Epub 2024 Sep 17.
6
DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5.异染色质中 DNA 双链断裂的移动依赖于组蛋白乙酰转移酶 dGcn5。
Nucleic Acids Res. 2024 Oct 28;52(19):11753-11767. doi: 10.1093/nar/gkae775.
7
Human Smc5/6 recognises transcription-generated positive DNA supercoils.人 Smc5/6 识别转录产生的正 DNA 超螺旋。
Nat Commun. 2024 Sep 6;15(1):7805. doi: 10.1038/s41467-024-50646-w.
8
RAD18 directs DNA double-strand break repair by homologous recombination to post-replicative chromatin.RAD18 通过同源重组指导 DNA 双链断裂修复到复制后染色质。
Nucleic Acids Res. 2024 Jul 22;52(13):7687-7703. doi: 10.1093/nar/gkae499.
9
Light signaling in plants-a selective history.植物中的光信号——选择性历史。
Plant Physiol. 2024 Apr 30;195(1):213-231. doi: 10.1093/plphys/kiae110.
10
Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis.光激发隐花色素与 ADA2b 和 SMC5 相互作用，促进拟南芥中 DNA 双链断裂的修复。
Nat Plants. 2023 Aug;9(8):1280-1290. doi: 10.1038/s41477-023-01461-6. Epub 2023 Jul 24.

本文引用的文献

1
Nonhomologous end joining in yeast.酵母中的非同源末端连接
Annu Rev Genet. 2005;39:431-51. doi: 10.1146/annurev.genet.39.073003.113340.
2
SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.SMC5和SMC6基因是重复染色体区域分离所必需的。
Nat Cell Biol. 2005 Apr;7(4):412-9. doi: 10.1038/ncb1239. Epub 2005 Mar 27.
3
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.DNA修复需要复制后将黏连蛋白招募到双链断裂处。
Mol Cell. 2004 Dec 22;16(6):1003-15. doi: 10.1016/j.molcel.2004.11.026.
4
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain.DNA损伤反应途径利用组蛋白修饰来组装一个双链断裂特异性黏连蛋白结构域。
Mol Cell. 2004 Dec 22;16(6):991-1002. doi: 10.1016/j.molcel.2004.11.027.
5
Equal sister chromatid exchange is a major mechanism of double-strand break repair in yeast.均等姐妹染色单体交换是酵母中双链断裂修复的主要机制。
Mol Cell. 2003 Jun;11(6):1661-71. doi: 10.1016/s1097-2765(03)00183-7.
6
NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae.NEJ1在酿酒酵母中控制非同源末端连接。
Nature. 2001 Dec 6;414(6864):666-9. doi: 10.1038/414666a.
7
Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.在酿酒酵母中，姐妹染色单体黏连对于复制后双链断裂修复是必需的。
Curr Biol. 2001 Jun 26;11(12):991-5. doi: 10.1016/s0960-9822(01)00271-8.
8
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination.SGS1是BLM和WRN在酿酒酵母中的同源物，可抑制基因组不稳定性和同源重组。
Nat Genet. 2001 Jan;27(1):113-6. doi: 10.1038/83673.
9
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.酿酒酵母中双链断裂诱导的多种重组途径。
Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404. doi: 10.1128/MMBR.63.2.349-404.1999.
10
Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases.酵母中的双链断裂修复需要前导链和后随链DNA聚合酶。
Cell. 1999 Feb 5;96(3):415-24. doi: 10.1016/s0092-8674(00)80554-1.

Smc5-Smc6通过促进姐妹染色单体重组来介导DNA双链断裂修复。

Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

作者信息

De Piccoli Giacomo, Cortes-Ledesma Felipe, Ira Gregory, Torres-Rosell Jordi, Uhle Stefan, Farmer Sarah, Hwang Ji-Young, Machin Felix, Ceschia Audrey, McAleenan Alexandra, Cordon-Preciado Violeta, Clemente-Blanco Andrés, Vilella-Mitjana Felip, Ullal Pranav, Jarmuz Adam, Leitao Beatriz, Bressan Debra, Dotiwala Farokh, Papusha Alma, Zhao Xiaolan, Myung Kyungjae, Haber James E, Aguilera Andrés, Aragón Luis

机构信息

Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.

出版信息

Nat Cell Biol. 2006 Sep;8(9):1032-4. doi: 10.1038/ncb1466. Epub 2006 Aug 6.

DOI:10.1038/ncb1466
PMID:16892052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4493748/
Abstract

DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.

摘要

DNA双链断裂（DSB）可在DNA复制过程中产生，或在暴露于DNA损伤剂后产生，其正确修复对于细胞存活和基因组稳定性至关重要。在此，我们表明Smc5-Smc6复合物被重新招募到DSB处，以通过姐妹染色单体之间的同源重组来支持其修复。此外，我们证明Smc5-Smc6对于抑制大规模染色体重排是必需的。我们的研究结果表明，Smc5-Smc6复合物对于基因组稳定性至关重要，因为它通过无差错的姐妹染色单体重组（SCR）促进DSB的修复，从而抑制不适当的非姐妹重组事件。