Jones Craig K, Schlosser Michael J, van Zijl Peter C M, Pomper Martin G, Golay Xavier, Zhou Jinyuan
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA.
Magn Reson Med. 2006 Sep;56(3):585-92. doi: 10.1002/mrm.20989.
Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water-exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole-body clinical scanner and compared with T1- (T1w) and T2-weighted (T2w), fluid-attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT-weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal-appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures.
酰胺质子转移（APT）成像是一种技术，其中组织内源性可移动蛋白质和肽的可与水交换的酰胺质子的核磁化被饱和，导致自由水的信号强度降低。在这项工作中，首次在3T全身临床扫描仪上从10名脑肿瘤患者获取了人体APT数据，并与T1加权（T1w）、T2加权（T2w）、液体衰减反转恢复（FLAIR）和扩散图像（分数各向异性（FA）和表观扩散系数（ADC））进行了比较。APT加权图像在肿瘤和水肿之间提供了良好的对比度。与水肿和正常外观白质（NAWM）相比，肿瘤区域的水信号强度大约有4%的变化，增强了APT的效果。来自脑肿瘤患者的这些初步数据表明，APT是一种独特的对比度，可为标准临床MRI测量提供补充信息。
