Sharma H S, Misra U K
Max-Planck Institute for Physiological and Clinical Research, Bad Nauheim, Federal Republic of Germany.
Experientia. 1990 Feb 15;46(2):208-11. doi: 10.1007/BF02027317.
The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 micrograms retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats.
在大鼠中研究了胎儿大脑的生化发育与母体维生素A限制的关系。通过在怀孕和哺乳期间分别提供低、中、适量（分别为6、40和100微克视黄醇/天/千克体重）的维生素A，改变怀孕大鼠的维生素A状态。母体维生素A限制导致胎儿大脑发育在组织重量、DNA、RNA和蛋白质水平以及分别由[3H] - 胸苷和[3H] - 亮氨酸合成DNA和蛋白质方面发生改变。在发育中的大鼠胎儿大脑中，观察到母体维生素A限制对DNA、RNA和蛋白质代谢具有剂量依赖性影响。
