Sharma H S, Misra U K
Acta Vitaminol Enzymol. 1985;7(1-2):85-91.
The effect of maternal vitamin A restriction on the biochemical development of fetal liver in rats has been studied. Vitamin A status of the dams has been varied by supplying low, medium and adequate (6.40 and 100 micrograms retinol equivalents/day/kg body weight respectively) amounts of vitamin A during pregnancy and suckling. The restricted supply of vitamin A to the mother resulted in the impaired growth and development of fetal liver in the parameters of tissue weight, DNA, RNA and protein levels, cell number and biosynthesis of DNA and protein from 3H-thymidine and 3H-leucine respectively. Results also indicated a dose dependent effect of vitamin A on the metabolism of DNA, RNA and protein in the developing liver.
已对母体维生素A限制对大鼠胎儿肝脏生化发育的影响进行了研究。在怀孕和哺乳期间，通过分别提供低、中、充足（分别为6.40和100微克视黄醇当量/天/千克体重）的维生素A量来改变母鼠的维生素A状态。母体维生素A供应受限导致胎儿肝脏在组织重量、DNA、RNA和蛋白质水平、细胞数量以及分别从3H-胸腺嘧啶核苷和3H-亮氨酸进行的DNA和蛋白质生物合成等参数方面的生长和发育受损。结果还表明维生素A对发育中肝脏的DNA、RNA和蛋白质代谢具有剂量依赖性影响。
