Sharma H S, Misra U K
Department of Biochemistry, Vallabhbhai Patel Chest Institute, Delhi, India.
Z Ernahrungswiss. 1988 Jun;27(2):119-25. doi: 10.1007/BF02021651.
The effect of restricted vitamin A supply to the mother on the biochemical development of the heart in rats has been studied. The vitamin A status of female rats was varied by supplying low, medium and adequate amounts (6, 40, 100 micrograms retinol/day/kg body weight respectively) of vitamin A during pregnancy and suckling. The vitamin A status of the mother caused an alteration in the developmental pattern of fetal heart in parameters of tissue weight, DNA, RNA and protein contents and the biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine respectively. A dose-dependent effect of vitamin A on the metabolism of DNA, RNA and protein was observed in the developing rat hearts. Hence, emphasis should be given to the adequate availability of vitamin A to dams for the normal growth and development of fetal organs.
研究了孕期和哺乳期限制母鼠维生素A供应对大鼠心脏生化发育的影响。通过在孕期和哺乳期分别供应低、中、适量（分别为6、40、100微克视黄醇/天/千克体重）的维生素A来改变雌性大鼠的维生素A状态。母体的维生素A状态导致胎儿心脏发育模式在组织重量、DNA、RNA和蛋白质含量参数以及分别从[3H] - 胸腺嘧啶核苷和[3H] - 亮氨酸合成DNA和蛋白质方面发生改变。在发育中的大鼠心脏中观察到维生素A对DNA、RNA和蛋白质代谢具有剂量依赖性影响。因此，应重视为母鼠提供充足的维生素A，以确保胎儿器官的正常生长发育。
