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大鼠肝脏、肺、心脏和大脑中维生素A的产后分布与母体维生素A状态的关系。

Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status.

作者信息

Sharma H S, Misra U K

出版信息

Biol Neonate. 1986;50(6):345-50. doi: 10.1159/000242619.

DOI:10.1159/000242619
PMID:3801562
Abstract

The effect of low, medium and adequate vitamin A (6, 40 and 100 micrograms/day/kg body weight) supplementation to the dams was studied on the accumulation of vitamin A in various tissues of the rat during postnatal growth. The restricted supply of vitamin A to the mother resulted in an impaired growth of pups and their organs. The maternal hepatic stores of vitamin A were related to their vitamin A intake, being lowest in the low group and highest in the adequate group during their fetal development. The plasma vitamin A levels of dams were comparable in three groups at birth and on 10th day of postnatal age. The vitamin A contents of fetal hepatic and extra-hepatic tissues (lung, heart and brain) were increased with the age of pups and this increase was observed to be dependent on the supply of vitamin A to the mother.

摘要

研究了给母鼠补充低、中、充足剂量维生素A(分别为6、40和100微克/天/千克体重)对出生后生长期间大鼠各组织中维生素A积累的影响。给母体限制供应维生素A会导致幼崽及其器官生长受损。母体肝脏中的维生素A储备与其维生素A摄入量有关,在胎儿发育期间,低剂量组最低,充足剂量组最高。三组母鼠在出生时和出生后第10天的血浆维生素A水平相当。胎儿肝脏和肝外组织(肺、心脏和大脑)中的维生素A含量随幼崽年龄增加而增加,且这种增加取决于母体维生素A的供应情况。

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