Willemze Rein
Leiden University Medical Center, Department of Dermatology, Leiden, The Netherlands.
Curr Opin Oncol. 2006 Sep;18(5):425-31. doi: 10.1097/01.cco.0000239879.31463.42.
There has been confusion and debate regarding the definition, terminology, and optimal treatment of the different types of primary cutaneous B-cell lymphomas. This review presents the new World Health Organization-European Organization for the Research and Treatment of Cancer classification for cutaneous lymphomas; describes clinicopathologic, immunophenotypic, and genetic features of the different types of cutaneous B-cell lymphomas in this classification; and discusses current views on treatment of these lymphomas.
The three main types of cutaneous B-cell lymphomas in this new classification are primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous large B-cell lymphoma (leg type). Primary cutaneous marginal zone B-cell and primary cutaneous follicle center lymphoma are indolent types with an excellent prognosis that should be treated primarily with nonaggressive therapies. Primary cutaneous large B-cell lymphoma (leg type) is an aggressive lymphoma that should be treated primarily with aggressive chemotherapy.
The World Health Organization-European Organization for the Research and Treatment of Cancer classification will contribute to uniform diagnosis, management, and treatment of patients with cutaneous B-cell lymphoma and will prevent patients with indolent types of the disease from being treated inappropriately with systemic chemotherapy.
关于不同类型原发性皮肤B细胞淋巴瘤的定义、术语及最佳治疗方法一直存在混淆和争议。本综述介绍了世界卫生组织-欧洲癌症研究与治疗组织对皮肤淋巴瘤的新分类；描述了该分类中不同类型皮肤B细胞淋巴瘤的临床病理、免疫表型及遗传学特征；并讨论了目前对这些淋巴瘤治疗的观点。
新分类中的三种主要皮肤B细胞淋巴瘤类型为原发性皮肤边缘区B细胞淋巴瘤、原发性皮肤滤泡中心淋巴瘤和原发性皮肤大B细胞淋巴瘤（腿部型）。原发性皮肤边缘区B细胞淋巴瘤和原发性皮肤滤泡中心淋巴瘤为惰性类型，预后良好，主要应采用非激进疗法治疗。原发性皮肤大B细胞淋巴瘤（腿部型）是一种侵袭性淋巴瘤，主要应采用激进化疗进行治疗。
世界卫生组织-欧洲癌症研究与治疗组织的分类将有助于对皮肤B细胞淋巴瘤患者进行统一的诊断、管理和治疗，并防止惰性类型疾病的患者接受不适当的全身化疗。
