Mantzoros Christos S, Williams Catherine J, Manson Joann E, Meigs James B, Hu Frank B
Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA and Nutrition, Harvard School of Public Health, Boston, MA, USA.
Am J Clin Nutr. 2006 Aug;84(2):328-35. doi: 10.1093/ajcn/84.1.328.
Although the typical diet of the Mediterranean region has received much recognition over the past several years for its association with substantial health benefits, it remains unknown whether its favorable effects are mediated through changes in adiponectin concentrations.
The objective was to determine whether adherence to a Mediterranean-type diet is associated with higher plasma adiponectin concentrations.
This study was a prospective and cross-sectional evaluation of plasma adiponectin concentrations and dietary data from 987 diabetic women from the Nurses' Health Study who had no history of cardiovascular disease at the time blood was drawn in 1990.
Women who scored highest on a 9-point scale that measures adherence to a Mediterranean-type dietary pattern tended to be older, were less likely to be current smokers, had lower body mass indexes and waist circumferences, and had higher total energy intakes, physical activities, and plasma adiponectin concentrations than did women with the lowest scores. Median plasma adiponectin concentrations were 23% higher in women who most closely followed a Mediterranean-type diet than in low adherers after adjustment for age and energy intake (P < 0.01). Body composition, lifestyle, and medical history explained some, but not all, of the observed association between diet and adiponectin concentrations because high adherers tended to have greater adiponectin concentrations than did moderate or low adherers, even after adjustment for these variables.
Our data suggest that, of the several components of the Mediterranean dietary pattern score, alcohol, nuts, and whole grains show the strongest association with adiponectin concentrations. Close adherence to a Mediterranean-type diet is associated with higher adiponectin concentrations.
尽管地中海地区的典型饮食在过去几年因其与诸多健康益处相关联而备受认可，但尚不清楚其有益效果是否通过脂联素浓度的变化介导。
确定坚持地中海式饮食是否与较高的血浆脂联素浓度相关。
本研究是对987名来自护士健康研究的糖尿病女性的血浆脂联素浓度和饮食数据进行的前瞻性横断面评估，这些女性在1990年采血时无心血管疾病史。
在衡量对地中海式饮食模式依从性的9分制量表上得分最高的女性往往年龄较大，当前吸烟者较少，体重指数和腰围较低，总能量摄入量、身体活动量和血浆脂联素浓度均高于得分最低的女性。在调整年龄和能量摄入后，最严格遵循地中海式饮食的女性的血浆脂联素浓度中位数比低依从者高23%（P<0.01）。身体组成、生活方式和病史解释了饮食与脂联素浓度之间观察到的部分而非全部关联，因为即使在调整这些变量后，高依从者的脂联素浓度仍往往高于中度或低依从者。
我们的数据表明，在地中海饮食模式评分的几个组成部分中，酒精、坚果和全谷物与脂联素浓度的关联最强。严格坚持地中海式饮食与较高的脂联素浓度相关。
