Ford Earl S, Schleicher Rosemary L, Mokdad Ali H, Ajani Umed A, Liu Simin
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Am J Clin Nutr. 2006 Aug;84(2):375-83. doi: 10.1093/ajcn/84.1.375.
Although the population distribution of serum concentrations of alpha-tocopherol has been described in the United States, little is known about the distribution of gamma-tocopherol or the ratio of alpha-tocopherol to gamma-tocopherol.
Our aim was to describe the distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in a nationally representative sample of US adults.
We reviewed data from 4087 adults aged >/=20 y who participated in the National Health and Nutrition Examination Survey (1999-2000). Concentrations of alpha-tocopherol and gamma-tocopherol were measured by using HPLC with ultraviolet-visible wavelength detection.
The arithmetic mean (+/-SEM) of serum concentrations of alpha-tocopherol was 30.09 +/- 0.45 micromol/L, the median was 25.94 micromol/L, and the geometric mean (+/-SEM) was 27.39 +/- 0.38 micromol/L. The arithmetic mean of serum concentrations of gamma-tocopherol was 5.74 +/- 0.22 micromol/L, the median was 5.25 micromol/L, and the geometric mean was 4.79 +/- 0.18 micromol/L. The median ratio of alpha-tocopherol to total cholesterol was 4.93 micromol/mmol, that of gamma-tocopherol to total cholesterol was 1.03 micromol/mmol, and that of alpha-tocopherol to gamma-tocopherol was 4.53 micromol/mmol. Concentrations of alpha-tocopherol increased significantly (P for trend < 0.001) with age and were significantly (P = 0.015) lower in men than in women. African Americans and Mexican Americans had significantly (P < 0.001) lower concentrations of alpha-tocopherol than did whites. The median concentrations of gamma-tocopherol showed a trend with respect to age, did not differ significantly between men and women, and were slightly but nonsignificantly lower in white participants than in African American or Mexican American participants.
Sociodemographic variations in serum concentrations of alpha-tocopherol and gamma-tocopherol exist among US adults.
尽管在美国已描述了血清α-生育酚浓度的人群分布情况，但对于γ-生育酚的分布或α-生育酚与γ-生育酚的比值却知之甚少。
我们的目的是描述美国成年人全国代表性样本中血清α-生育酚和γ-生育酚浓度的分布情况。
我们回顾了4087名年龄≥20岁的成年人参与国家健康与营养检查调查（1999 - 2000年）的数据。使用配备紫外可见波长检测的高效液相色谱法测量α-生育酚和γ-生育酚的浓度。
血清α-生育酚浓度的算术平均值（±标准误）为30.09±0.45微摩尔/升，中位数为25.94微摩尔/升，几何平均值（±标准误）为27.39±0.38微摩尔/升。血清γ-生育酚浓度的算术平均值为5.74±0.22微摩尔/升，中位数为5.25微摩尔/升，几何平均值为4.79±0.18微摩尔/升。α-生育酚与总胆固醇的中位数比值为4.93微摩尔/毫摩尔，γ-生育酚与总胆固醇的比值为1.03微摩尔/毫摩尔，α-生育酚与γ-生育酚的比值为4.53微摩尔/毫摩尔。α-生育酚浓度随年龄显著增加（趋势P<0.001），且男性显著低于女性（P = 0.015）。非裔美国人和墨西哥裔美国人的α-生育酚浓度显著低于白人（P<0.001）。γ-生育酚的中位数浓度随年龄呈现一定趋势，男性和女性之间无显著差异，白人参与者的γ-生育酚浓度略低于非裔美国人或墨西哥裔美国人参与者，但差异不显著。
美国成年人血清α-生育酚和γ-生育酚浓度存在社会人口统计学差异。
