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轻度头部损伤后立即进行计算机断层扫描或住院观察:随机对照试验中的成本比较

Immediate computed tomography or admission for observation after mild head injury: cost comparison in randomised controlled trial.

作者信息

Norlund Anders, Marké Lars-Ake, af Geijerstam Jean-Luc, Oredsson Sven, Britton Mona

机构信息

Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, 171 76 Stockholm, Sweden.

出版信息

BMJ. 2006 Sep 2;333(7566):469. doi: 10.1136/bmj.38918.659120.4F. Epub 2006 Aug 8.

Abstract

OBJECTIVE

To compare the costs of immediate computed tomography during triage for admission with those of observation in hospital in patients with mild head injury.

DESIGN

Prospective cost effectiveness analysis within a multicentre, pragmatic randomised trial.

SETTING

39 acute hospitals in Sweden

PARTICIPANTS

2602 patients (aged > or = 6) with mild head injury.

INTERVENTIONS

Immediate computed tomography or admission for observation.

MAIN OUTCOME MEASURES

Direct and indirect costs related to the mild head injury during the acute and three month follow-up period.

RESULTS

Outcome after three months was similar for both strategies (non-significantly in favour of computed tomography). For the acute stage and complications, the cost was 461 euros (314 pounds sterling, 582 dollars) per patient in the computed tomography group and 677 euros (462 pounds sterling, 854 dollars) in the observation group; an average of 32% less in the computed tomography group (216 euros, 95% confidence interval -272 to -164; P < 0.001). Sensitivity analysis showed that computed tomography was the most cost effective strategy under a broad range of assumptions. After three months, total costs were 718 euros and 914 euros per patient-that is, 196 euros less in the computed tomography group (- 281 to - 114; P < 0.001). The lower cost of the computed tomography strategy at the acute stage thus remained unchanged during follow-up.

CONCLUSION

Patients with mild head injury attending an emergency department can be managed more cost effectively with computed tomography rather than admission for observation in hospital.

TRIAL REGISTRATION

ISRCTN81464462.

摘要

目的

比较轻度颅脑损伤患者分诊时立即进行计算机断层扫描与住院观察的费用。

设计

在一项多中心、实用的随机试验中进行前瞻性成本效益分析。

地点

瑞典的39家急症医院

参与者

2602例轻度颅脑损伤患者(年龄≥6岁)。

干预措施

立即进行计算机断层扫描或住院观察。

主要观察指标

急性及三个月随访期内与轻度颅脑损伤相关的直接和间接费用。

结果

两种策略三个月后的结果相似(计算机断层扫描组略占优势,但无统计学意义)。对于急性期和并发症,计算机断层扫描组每位患者的费用为461欧元(314英镑,582美元),观察组为677欧元(462英镑,854美元);计算机断层扫描组平均少32%(216欧元,95%可信区间-272至-164;P<0.001)。敏感性分析表明,在广泛的假设下,计算机断层扫描是最具成本效益的策略。三个月后,每位患者的总费用分别为718欧元和914欧元,即计算机断层扫描组少196欧元(-281至-114;P<0.001)。因此,计算机断层扫描策略在急性期较低的成本在随访期间保持不变。

结论

急诊科的轻度颅脑损伤患者采用计算机断层扫描而非住院观察进行管理更具成本效益。

试验注册号

ISRCTN81464462

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