Pittrow David, Stalla Günther Karl, Zeiher Andreas M, Silber Sigmund, März Winfried, Pieper Lars, Klotsche Jens, Glaesmer Heide, Ruf Günther, Schneider Harald Jörn, Lehnert Hendrik, Böhler Steffen, Koch Uwe, Wittchen Hans-Ulrich
Institut für Klinische Pharmakologie, Forschungsverbund Public Health, Technische Universität Dresden, Dresden, Germany.
Med Klin (Munich). 2006 Aug 15;101(8):635-44. doi: 10.1007/s00063-006-1093-x.
The primary care sector is of key importance for the management of patients with diabetes mellitus. The authors investigated (a) the prevalence of diabetes mellitus type 1 and type 2, (b) the type and frequency of non-drug and drug treatment and its association with the presence of diabetic complications, and (c) the quality of metabolic control by HbA1c.
Using a nationwide probability sample of 3,188 general practices (response rate [RR] 50.6%), a total of 55,518 (RR 93.5%) patients were assessed in a prospective cross-sectional study by their physicians in September 2003 in a standardized manner using questionnaires, physician interview, and laboratory assessments. In addition to diabetes mellitus, 28 diseases were explicitly screened for, among them typical macrovascular (coronary heart disease, cerebrovascular disease, peripheral arterial disease) and microvascular disease (neuropathy, nephropathy, retinopathy, diabetic foot) complications.
The prevalence of diabetes mellitus was 0.5% (type 1) and 14.7% (type 2), respectively. 49.5% (type 1) and 50.2% (type 2) of patients had micro- or macrovascular complications. 6.8% did not receive any treatment, 13.5% received non-drug treatment, and 75.3% received oral antidiabetic drugs and/or insulin (26.6% a combination of two or more). Compared to diabetics without any complications, treatment intensity was significantly higher in patients with microvascular complications (odds ratio [OR] 3.02), but not in those with macrovascular complications only (OR 0.98). An HbA1c value>or=7.0% was recorded in 39.6% of patients.
Compared to previous studies in this setting, the proportion of diabetics with drug treatment has increased. More patients receive antidiabetic drug combinations. Quality of blood sugar control appears to have improved as well.
基层医疗部门对于糖尿病患者的管理至关重要。作者调查了:(a)1型和2型糖尿病的患病率;(b)非药物和药物治疗的类型及频率及其与糖尿病并发症的关联;(c)糖化血红蛋白(HbA1c)所反映的代谢控制质量。
采用全国范围内3188家普通诊所的概率样本(应答率[RR]50.6%),在一项前瞻性横断面研究中,2003年9月,其医生使用问卷、医生访谈及实验室评估等标准化方式,对总计55518名患者(应答率93.5%)进行了评估。除糖尿病外,还对28种疾病进行了明确筛查,其中包括典型的大血管(冠心病、脑血管疾病、外周动脉疾病)和微血管疾病(神经病变、肾病、视网膜病变、糖尿病足)并发症。
糖尿病的患病率分别为0.5%(1型)和14.7%(2型)。49.5%(1型)和50.2%(2型)的患者有微血管或大血管并发症。6.8%的患者未接受任何治疗,13.5%接受非药物治疗,75.3%接受口服降糖药和/或胰岛素治疗(26.6%使用两种或更多药物联合治疗)。与无任何并发症的糖尿病患者相比,微血管并发症患者的治疗强度显著更高(优势比[OR]3.02),但仅患有大血管并发症的患者并非如此(OR 0.98)。39.6%的患者糖化血红蛋白值≥7.0%。
与此前在此环境下的研究相比,接受药物治疗的糖尿病患者比例有所增加。更多患者接受降糖药物联合治疗。血糖控制质量似乎也有所改善。