Galbussera A, Tremolizzo L, Brighina L, Testa D, Lovati R, Ferrarese C, Cavaletti G, Filippini G
Department of Neurology, S. Gerardo Hospital and University of Milano-Bicocca, Via Donizetti 106, I-20052, Monza (MI), Italy.
Neurol Sci. 2006 Jul;27(3):190-3. doi: 10.1007/s10072-006-0668-x.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving both upper and lower motor neurons, leading inexorably to death within a few years. Although our understanding of the pathogenesis of this disease has grown at a very fast rate in recent years, we do not yet have effective treatment options that can positively impact the quality of life (QoL) of these patients. Interestingly, increasing experimental evidence suggests that oxidative stress is involved in the pathogenesis of ALS and that vitamin E could reduce neuronal damage. Hence, in this observational study we determined the QoL in 33 ALS patients taking or not taking vitamin E supplementation (600 mg/day), using the Italian version of the Short-Form 36-Item Health Survey (SF-36). No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue.
肌萎缩侧索硬化症（ALS）是一种涉及上下运动神经元的神经退行性疾病，数年内必然导致死亡。尽管近年来我们对这种疾病发病机制的理解有了飞速进展，但我们仍没有能够切实影响这些患者生活质量（QoL）的有效治疗方案。有趣的是，越来越多的实验证据表明氧化应激参与了ALS的发病机制，并且维生素E可以减少神经元损伤。因此，在这项观察性研究中，我们使用意大利语版的简短36项健康调查（SF-36）确定了33例服用或未服用维生素E补充剂（600毫克/天）的ALS患者的生活质量。两组患者之间未观察到差异，因此我们不建议在ALS患者中常规使用维生素E至少在没有专门针对解决此问题设计的随机临床试验的情况下不建议使用。
