土拉普贝辛A和B，是从柔毛杜楝中分离得到的天然含卤和含马来酰亚胺的柠檬苦素的首个实例。

Turrapubesins A and B, first examples of halogenated and maleimide-bearing limonoids in nature from Turraea pubescens.

作者信息

Wang Xiao-Ning, Yin Sheng, Fan Cheng-Qi, Wang Fang-Dao, Lin Li-Ping, Ding Jian, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

出版信息

Org Lett. 2006 Aug 17;8(17):3845-8. doi: 10.1021/ol061466a.

DOI:10.1021/ol061466a

PMID:16898832

Abstract

[structure: see text] Two novel tetranortriterpenoids, turrapubesins A (1) and B (2), representing the first examples of halogenated and maleimide-bearing limonoids, were isolated from the twigs and leaves of Turraea pubescens. The structures of 1 and 2 were elucidated by extensive spectroscopic analysis. Their absolute configurations were determined by X-ray crystallography of 1 and by CD analysis of a dihydrogenated derivative of 2. Turrapubesin A (1) exhibited weak cytotoxicity against the P-388 tumor cell line.

摘要

[结构：见正文] 从柔毛杜瑞木的嫩枝和叶子中分离出两种新型四降三萜类化合物，柔毛杜瑞木素A（1）和B（2），它们是首次发现的含卤代和马来酰亚胺的柠檬苦素类化合物。通过广泛的光谱分析阐明了1和2的结构。它们的绝对构型通过1的X射线晶体学分析和2的二氢化衍生物的圆二色性分析确定。柔毛杜瑞木素A（1）对P-388肿瘤细胞系表现出微弱的细胞毒性。