[慢性化脓性中耳炎患者中耳培养物中分离出的微生物及其抗菌药敏性]

[Microorganisms isolated from middle ear cultures and their antibacterial susceptibility in patients with chronic suppurative otitis media].

作者信息

Gül H Cem, Kurnaz Ali, Turhan Vedat, Oncül Oral, Pahsa Alahattin

机构信息

Department of Infectious Diseases, Gümüşsuyu Military Hospital, Istanbul, Turkey.

出版信息

Kulak Burun Bogaz Ihtis Derg. 2006;16(4):164-8.

DOI:

PMID:16905907

Abstract

OBJECTIVES

This study sought to determine causative microorganisms of chronic suppurative otitis media and their antibacterial susceptibility.

PATIENTS AND METHODS

Bacteriologic results of middle ear swabs, agent microorganisms, and their susceptibility to antibiotics were evaluated in 70 patients (65 males, 5 females; mean age 21.1+/-1.3 years; range 19 to 25 years) with chronic suppurative otitis media.

RESULTS

No bacteria were isolated in 14% of the patients. Of 60 patients in whom bacteria were isolated, the most common bacteria was Pseudomonas aeruginosa (23%), followed by Staphylococcus aureus (18%), and Proteus spp. (17%). P. aeruginosa strains were susceptible to ceftazidime and imipenem (100%), ciprofloxacin (92%), and amikacin and gentamycin (85%); S. aureus strains were susceptible to methicillin and vancomycin (100%), ciprofloxacin (91%), sulbactam-ampicillin (73%), and gentamycin and trimethoprim-sulfamethoxazole (63%). Proteus strains were susceptible to ciprofloxacin (100%), ceftazidime (90%), and imipenem and gentamycin (70%).

CONCLUSION

Appropriate knowledge of antibacterial susceptibility of microorganisms will contribute to rational antibiotic usage and the success of treatment for chronic suppurative otitis media.

摘要

目的

本研究旨在确定慢性化脓性中耳炎的致病微生物及其抗菌药敏情况。

患者与方法

对70例慢性化脓性中耳炎患者（男65例，女5例；平均年龄21.1±1.3岁；年龄范围19至25岁）的中耳拭子细菌学结果、致病微生物及其对抗生素的敏感性进行了评估。

结果

14%的患者未分离出细菌。在分离出细菌的60例患者中，最常见的细菌是铜绿假单胞菌（23%），其次是金黄色葡萄球菌（18%）和变形杆菌属（17%）。铜绿假单胞菌菌株对头孢他啶和亚胺培南敏感（100%），对环丙沙星敏感（92%），对阿米卡星和庆大霉素敏感（85%）；金黄色葡萄球菌菌株对甲氧西林和万古霉素敏感（100%），对环丙沙星敏感（91%），对舒巴坦-氨苄西林敏感（73%），对庆大霉素和复方新诺明敏感（63%）。变形杆菌菌株对环丙沙星敏感（100%），对头孢他啶敏感（90%），对亚胺培南和庆大霉素敏感（70%）。