Norlén H, Dimberg M, Vinnars E, Allgén L G, Brandt R
Department of Urology, St Göran's Hospital, Stockholm, Sweden.
Scand J Urol Nephrol. 1990;24(1):21-6. doi: 10.3109/00365599009180354.
10 patients undergoing transurethral resection of the prostate using sterile distilled water as an irrigating fluid were studied. The extra- and intracellular distribution of water, the total content of water and electrolytes and the free amino acid concentrations in muscle tissue were determined together with the concentrations of free amino acids in plasma preoperatively, immediately postoperatively and 2 hours postoperatively. The content of water and concentrations of electrolytes in skeletal muscle did not change significantly from the preoperative to the postoperative period with the exception of the potassium concentration, which decreased 2 hours postoperatively. The following free amino acid concentrations in muscle tissue showed significantly decreased values 2 hours postoperatively compared with the preoperative values: taurine, serine, glutamate, proline and leucine. The concentrations of non-essential amino acids in muscle decreased significantly 2 hours postoperatively. This may be interpreted as a dilution effect. An increased concentration of some amino acids in plasma postoperatively may be explained as a haemoconcentration effect due to the use of a postoperative diuretic.
对10例使用无菌蒸馏水作为冲洗液进行经尿道前列腺切除术的患者进行了研究。测定了术前、术后即刻及术后2小时肌肉组织中水分的细胞外和细胞内分布、水和电解质的总含量以及游离氨基酸浓度，同时测定了血浆中游离氨基酸浓度。除术后2小时钾浓度降低外，骨骼肌中水分含量和电解质浓度从术前到术后无显著变化。与术前值相比，术后2小时肌肉组织中以下游离氨基酸浓度显著降低：牛磺酸、丝氨酸、谷氨酸、脯氨酸和亮氨酸。术后2小时肌肉中非必需氨基酸浓度显著降低。这可能被解释为稀释效应。术后血浆中某些氨基酸浓度升高可能是由于术后使用利尿剂导致的血液浓缩效应所致。
