Shutter Lori, Tong Karen A, Lee Ann, Holshouser Barbara A
Department of Neurosurgery, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA.
J Head Trauma Rehabil. 2006 Jul-Aug;21(4):334-49. doi: 10.1097/00001199-200607000-00005.
Proton magnetic resonance spectroscopy (MRS) is being used to evaluate individuals after acute traumatic brain injury. These studies have shown that changes in certain brain metabolites are associated with poor neurologic outcomes. The majority of MRS studies have been obtained relatively late after injury, but there have been a few reports of use early after injury to assist with outcome prediction. Altered brain metabolites may be sensitive indicators of injury and thus provide additional prognostic information when spectroscopy is done early after injury. This technology may provide a noninvasive means to evaluate early excitotoxic injury, and show changes associated with both neuronal injury and membrane disruption secondary to diffuse axonal injury. This article will review the technology of MRS, discuss its role in patient assessment after traumatic brain injury, and present a summary of our published and ongoing research.
质子磁共振波谱（MRS）正被用于评估急性创伤性脑损伤后的个体。这些研究表明，某些脑代谢物的变化与不良神经学预后相关。大多数MRS研究是在损伤后相对较晚的时候进行的，但也有一些关于在损伤后早期使用以辅助预后预测的报道。脑代谢物的改变可能是损伤的敏感指标，因此在损伤后早期进行波谱分析时可提供额外的预后信息。这项技术可能提供一种非侵入性手段来评估早期兴奋性毒性损伤，并显示与弥漫性轴索损伤继发的神经元损伤和膜破坏相关的变化。本文将回顾MRS技术，讨论其在创伤性脑损伤患者评估中的作用，并总结我们已发表和正在进行的研究。
