小鼠基因组诱变计划的欧洲层面
The European dimension for the mouse genome mutagenesis program.
作者信息
Auwerx Johan, Avner Phil, Baldock Richard, Ballabio Andrea, Balling Rudi, Barbacid Mariano, Berns Anton, Bradley Allan, Brown Steve, Carmeliet Peter, Chambon Pierre, Cox Roger, Davidson Duncan, Davies Kay, Duboule Denis, Forejt Jiri, Granucci Francesca, Hastie Nick, de Angelis Martin Hrabé, Jackson Ian, Kioussis Dimitris, Kollias George, Lathrop Mark, Lendahl Urban, Malumbres Marcos, von Melchner Harald, Müller Werner, Partanen Juha, Ricciardi-Castagnoli Paola, Rigby Peter, Rosen Barry, Rosenthal Nadia, Skarnes Bill, Stewart A Francis, Thornton Janet, Tocchini-Valentini Glauco, Wagner Erwin, Wahli Walter, Wurst Wolfgang
机构信息
Mouse Clinical Institute (MCI), Illkirch, Strasbourg, France [corrected].
出版信息
Nat Genet. 2004 Sep;36(9):925-7. doi: 10.1038/ng0904-925.
Abstract
The European Mouse Mutagenesis Consortium is the European initiative contributing to the international effort on functional annotation of the mouse genome. Its objectives are to establish and integrate mutagenesis platforms, gene expression resources, phenotyping units, storage and distribution centers and bioinformatics resources. The combined efforts will accelerate our understanding of gene function and of human health and disease.
摘要
欧洲小鼠诱变联盟是欧洲的一项倡议，为小鼠基因组功能注释的国际努力做出贡献。其目标是建立并整合诱变平台、基因表达资源、表型分析单位、储存与分发中心以及生物信息学资源。这些共同努力将加速我们对基因功能以及人类健康与疾病的理解。
相似文献
1
The European dimension for the mouse genome mutagenesis program.小鼠基因组诱变计划的欧洲层面
Nat Genet. 2004 Sep;36(9):925-7. doi: 10.1038/ng0904-925.
2
The functional annotation of mammalian genomes: the challenge of phenotyping.哺乳动物基因组的功能注释：表型分析的挑战。
Annu Rev Genet. 2009;43:305-33. doi: 10.1146/annurev-genet-102108-134143.
3
EUCOMM--the European conditional mouse mutagenesis program.欧盟条件性小鼠诱变计划（EUCOMM）
Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5. doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29.
4
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.小鼠大规模表型分析计划：欧洲小鼠疾病临床中心（EUMODIC）和惠康信托桑格研究所小鼠遗传学项目概述。
Mamm Genome. 2012 Oct;23(9-10):600-10. doi: 10.1007/s00335-012-9418-y. Epub 2012 Sep 9.
5
Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.理解哺乳动物遗传系统：小鼠表型分析的挑战。
PLoS Genet. 2006 Aug 25;2(8):e118. doi: 10.1371/journal.pgen.0020118.
6
Phenosite: a web database integrating the mouse phenotyping platform and the experimental procedures in mice.Phenosite：一个整合小鼠表型分析平台和小鼠实验程序的网络数据库。
J Bioinform Comput Biol. 2007 Dec;5(6):1173-91. doi: 10.1142/s0219720007003168.
7
Sequence interpretation. Functional annotation of mouse genome sequences.序列解读。小鼠基因组序列的功能注释。
Science. 2001 Feb 16;291(5507):1251-5. doi: 10.1126/science.1058244.
8
Large-scale mutational analysis for the annotation of the mouse genome.用于小鼠基因组注释的大规模突变分析。
Curr Opin Chem Biol. 2002 Feb;6(1):17-23. doi: 10.1016/s1367-5931(01)00277-0.
9
Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis.美国国立卫生研究院（NIH）关于小鼠表型分析和诱变的跨部门神经科学计划。
Mamm Genome. 2001 Aug;12(8):575-81. doi: 10.1007/s00335-001-4005-7.
10
Progress towards completing the mutant mouse null resource.完成突变小鼠缺失资源的进展。
Mamm Genome. 2022 Mar;33(1):123-134. doi: 10.1007/s00335-021-09905-0. Epub 2021 Oct 26.
引用本文的文献
1
A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research.一种用于纤毛相关基因及其体内资源的优先级工具，为纤毛病研究开辟了新途径。
Dis Model Mech. 2024 Oct 1;17(10). doi: 10.1242/dmm.052000. Epub 2024 Oct 14.
2
Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome.评论：国际小鼠表型分析联盟：哺乳动物基因组的高通量体内功能注释。
Mamm Genome. 2024 Dec;35(4):537-543. doi: 10.1007/s00335-024-10068-x. Epub 2024 Sep 10.
3
Genome Wide Conditional Mouse Knockout Resources.全基因组条件性小鼠敲除资源
Drug Discov Today Dis Models. 2016 Summer;20:3-12. doi: 10.1016/j.ddmod.2017.08.002. Epub 2017 Sep 12.
4
SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis.SRC 和 TKS5 介导成纤维细胞的足突形成促进细胞外基质浸润和肺纤维化。
Nat Commun. 2023 Sep 21;14(1):5882. doi: 10.1038/s41467-023-41614-x.
5
Mouse mutagenesis and phenotyping to generate models of development and disease.利用小鼠诱变和表型分析构建发育和疾病模型。
Curr Top Dev Biol. 2022;148:1-12. doi: 10.1016/bs.ctdb.2022.02.012. Epub 2022 Mar 24.
6
Progress towards completing the mutant mouse null resource.完成突变小鼠缺失资源的进展。
Mamm Genome. 2022 Mar;33(1):123-134. doi: 10.1007/s00335-021-09905-0. Epub 2021 Oct 26.
7
Principles of Genetic Engineering.遗传工程原理。
Genes (Basel). 2020 Mar 10;11(3):291. doi: 10.3390/genes11030291.
8
The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice.富含亮氨酸的酸性蛋白 Anp32b 是小鼠炎症的免疫调节剂。
Sci Rep. 2019 Mar 19;9(1):4853. doi: 10.1038/s41598-019-41269-z.
9
Genetic cartography of longevity in humans and mice: Current landscape and horizons.人类和小鼠长寿的遗传图谱：现状与展望。
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2718-2732. doi: 10.1016/j.bbadis.2018.01.026. Epub 2018 Feb 2.
10
Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.小鼠基因组信息学（MGI）资源：实验室小鼠的遗传、基因组和生物学知识库。
ILAR J. 2017 Jul 1;58(1):17-41. doi: 10.1093/ilar/ilx013.
本文引用的文献
1
The knockout mouse project.基因敲除小鼠项目。
Nat Genet. 2004 Sep;36(9):921-4. doi: 10.1038/ng0904-921.
2
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.谈一场变革：位点特异性重组酶对小鼠遗传分析的影响
Dev Cell. 2004 Jan;6(1):7-28. doi: 10.1016/s1534-5807(03)00399-x.
3
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.一种用于小鼠基因组功能分析的大规模、基因驱动的诱变方法。
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. doi: 10.1073/pnas.1633296100. Epub 2003 Aug 6.
4
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.小鼠基因组的高通量工程技术与高分辨率表达分析相结合。
Nat Biotechnol. 2003 Jun;21(6):652-9. doi: 10.1038/nbt822. Epub 2003 May 5.
5
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.海湾基因组学：小鼠胚胎干细胞插入突变资源库。
Nucleic Acids Res. 2003 Jan 1;31(1):278-81. doi: 10.1093/nar/gkg064.
6
A gene expression map of human chromosome 21 orthologues in the mouse.小鼠中人类21号染色体直系同源基因的表达图谱。
Nature. 2002 Dec 5;420(6915):586-90. doi: 10.1038/nature01270.
7
Human chromosome 21 gene expression atlas in the mouse.小鼠中的人类21号染色体基因表达图谱。
Nature. 2002 Dec 5;420(6915):582-6. doi: 10.1038/nature01178.
8
Recombineering: a powerful new tool for mouse functional genomics.重组工程：用于小鼠功能基因组学的强大新工具。
Nat Rev Genet. 2001 Oct;2(10):769-79. doi: 10.1038/35093556.
9
Site- and time-specific gene targeting in the mouse.小鼠中位点和时间特异性的基因靶向
Methods. 2001 May;24(1):71-80. doi: 10.1006/meth.2001.1159.
10
Sequence interpretation. Functional annotation of mouse genome sequences.序列解读。小鼠基因组序列的功能注释。
Science. 2001 Feb 16;291(5507):1251-5. doi: 10.1126/science.1058244.
Zotero 插件