Qiu Hongjin, Yang Jian, Kodali Pradeep, Koh Jason, Ameer Guillermo A
Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, E310 Evanston, IL 60208, USA.
Biomaterials. 2006 Dec;27(34):5845-54. doi: 10.1016/j.biomaterials.2006.07.042. Epub 2006 Aug 21.
We describe a novel approach to process bioceramic microparticles and poly(diol citrates) into bioceramic-elastomer composites for potential use in orthopedic surgery. The composite consists of the biodegradable elastomer poly(1,8-octanediol-citrate) (POC) and the bioceramic hydroxyapatite (HA). The objective of this work was to characterize POC-HA composites and assess the feasibility of fabricating tissue fixation devices using machining and molding techniques. The mechanical properties of POC-HA composites with HA (40, 50, 60, 65wt.%) were within the range of values reported for tissue fixation devices (for POC-HA 65wt.%, S(b)=41.4+/-3.1, E(b)=501.7+/-40.3, S(c)=74.6+/-9.0, E(c)=448.8+/-27.0, S(t)=9.7+/-2.3, E(t)=334.8+/-73.5, S(s)=27.7+/-2.4, T(s)=27.3+/-4.9, all values in MPa). At 20 weeks, the weight loss of POC-HA composites ranged between 8 and 12wt.%, with 65wt.% HA composites degrading the slowest. Exposure of POC-HA to simulated body fluid resulted in extensive mineralization in the form of calcium phosphate with Ca/P of 1.5-1.7 similar to bone. POC-HA supported osteoblast adhesion in vitro and histology results from POC-HA samples that were implanted in rabbit knees for 6 weeks suggest that the composite is biocompatible. Synthesis of POC-HA is easy and inexpensive, does not involve harsh solvents or initiators, and the mechanical properties of POC-HA with 65wt.% HA are suitable for the fabrication of potentially osteoconductive bone screws.
我们描述了一种将生物陶瓷微粒和聚（柠檬酸二醇酯）加工成生物陶瓷 - 弹性体复合材料的新方法，该复合材料有望用于骨科手术。这种复合材料由可生物降解的弹性体聚（1,8 - 辛二醇 - 柠檬酸酯）（POC）和生物陶瓷羟基磷灰石（HA）组成。这项工作的目的是表征POC - HA复合材料，并评估使用加工和成型技术制造组织固定装置的可行性。含有HA（40、50、60、65重量%）的POC - HA复合材料的力学性能在组织固定装置报道的值范围内（对于POC - HA 65重量%，S(b)=41.4±3.1，E(b)=501.7±40.3，S(c)=74.6±9.0，E(c)=448.8±27.0，S(t)=9.7±2.3，E(t)=334.8±73.5，S(s)=27.7±2.4，T(s)=27.3±4.9，所有值的单位为MPa）。在20周时，POC - HA复合材料的重量损失在8%至12%之间，其中65重量% HA的复合材料降解最慢。POC - HA暴露于模拟体液会导致以磷酸钙形式的广泛矿化，Ca/P为1.5 - 1.7，类似于骨骼。POC - HA在体外支持成骨细胞粘附，并且将POC - HA样品植入兔膝关节6周的组织学结果表明该复合材料具有生物相容性。POC - HA的合成简便且成本低廉，不涉及苛刻的溶剂或引发剂，并且含有65重量% HA的POC - HA的力学性能适合制造潜在的骨传导性骨螺钉。
