Laurenzi M A, Persson M A, Dalsgaard C J, Haegerstrand A
Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden.
Scand J Immunol. 1990 Apr;31(4):529-33. doi: 10.1111/j.1365-3083.1990.tb02801.x.
Substance P (SP) has recently been reported to induce interleukin 1 (IL-1) production by human monocytes. This was confirmed in our experiments with human monocytes cultivated in the presence of SP or SP together with lipopolysaccharide (LPS). In addition, a wide variability of cell response to the neuropeptide was noticed. Three out of twelve cell cultures were directly stimulated by SP to release IL-1, while four additional cultures needed prestimulation with suboptimal doses of LPS, and no effect was seen in the five remaining experiments. The data may suggest that preferentially activated monocytes respond to SP. The production of IL-1 by SP-stimulated monocytes is of great interest considering the broad spectrum of activity of IL-1 and the increasing evidence of sensory neuron involvement in acute and chronic inflammatory responses.
最近有报道称，P物质（SP）可诱导人单核细胞产生白细胞介素1（IL-1）。我们用人单核细胞在SP或SP与脂多糖（LPS）共同存在的条件下进行培养的实验证实了这一点。此外，还注意到细胞对该神经肽的反应存在很大差异。在十二份细胞培养物中，有三份被SP直接刺激释放IL-1，另有四份培养物需要用次优剂量的LPS进行预刺激，而在其余五个实验中未观察到效果。这些数据可能表明，优先被激活的单核细胞对SP有反应。考虑到IL-1广泛的活性谱以及感觉神经元参与急性和慢性炎症反应的证据越来越多，SP刺激的单核细胞产生IL-1这一现象备受关注。
