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本文引用的文献

1
Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.组胺通过派尔集合淋巴结中的H(2)受体发出信号，这对于控制小肠结肠炎耶尔森菌感染很重要。
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9268-73. doi: 10.1073/pnas.0510414103. Epub 2006 May 22.
2
Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model.使用鼻内感染模型鉴定肺炎克雷伯菌的毒力决定因素。
Mol Microbiol. 2005 Nov;58(4):1054-73. doi: 10.1111/j.1365-2958.2005.04918.x.
3
Lipopolysaccharide-mediated protection against Klebsiella pneumoniae-induced lobar pneumonia: intranasal vs. intramuscular route of immunization.脂多糖介导的针对肺炎克雷伯菌诱导的大叶性肺炎的保护作用：经鼻与肌肉注射免疫途径
Folia Microbiol (Praha). 2005;50(1):83-6. doi: 10.1007/BF02931298.
4
Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae.肺炎克雷伯菌肺部感染后白细胞介素-1基因敲除小鼠的代偿反应
J Med Microbiol. 2005 Jan;54(Pt 1):7-13. doi: 10.1099/jmm.0.45736-0.
5
Protective role of liposome incorporated lipopolysaccharide antigen of Klebsiella pneumoniae in a rat model of lobar pneumonia.肺炎克雷伯菌脂质体包裹脂多糖抗原在大鼠大叶性肺炎模型中的保护作用
Jpn J Infect Dis. 2004 Aug;57(4):150-5.
6
Biofilm formation in vitro and virulence in vivo of mutants of Klebsiella pneumoniae.肺炎克雷伯菌突变体的体外生物膜形成及体内毒力
Infect Immun. 2004 Aug;72(8):4888-90. doi: 10.1128/IAI.72.8.4888-4890.2004.
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Characterization of oral Yersinia enterocolitica infection in three different strains of inbred mice.三种不同近交系小鼠口腔小肠结肠炎耶尔森菌感染的特征分析
Infect Immun. 2004 Mar;72(3):1645-56. doi: 10.1128/IAI.72.3.1645-1656.2004.
8
Contribution of capsular and lipopolysaccharide antigens to the pathogenesis of Klebsiella pneumoniae respiratory tract infection.荚膜和脂多糖抗原在肺炎克雷伯菌呼吸道感染发病机制中的作用。
Folia Microbiol (Praha). 2003;48(5):699-702. doi: 10.1007/BF02993481.
9
The pathogenicity of Klebsiella pneumoniae for mice: the relationship to the quantity and rate of production of type-specific capsular polysaccharide.肺炎克雷伯菌对小鼠的致病性：与特定类型荚膜多糖产量及产生速率的关系。
J Bacteriol. 1956 Nov;72(5):713-7. doi: 10.1128/jb.72.5.713-717.1956.
10
Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies.荚膜在肺炎克雷伯菌毒力中的作用：体外研究与体内研究之间缺乏相关性。
FEMS Microbiol Lett. 2003 Jan 21;218(1):149-54. doi: 10.1111/j.1574-6968.2003.tb11511.x.

宿主对野生型和cpsB突变型肺炎克雷伯菌感染的反应比较。

Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections.

作者信息

Lawlor Matthew S, Handley Scott A, Miller Virginia L

机构信息

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

出版信息

Infect Immun. 2006 Sep;74(9):5402-7. doi: 10.1128/IAI.00244-06.

DOI:10.1128/IAI.00244-06
PMID:16926436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1594822/
Abstract

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

摘要

此前，我们建立了肺炎克雷伯菌感染的鼻内小鼠模型，并使用高毒力野生型菌株和无毒力荚膜多糖突变体验证了其效用。在本研究中，我们通过检测细胞因子产生、细胞浸润、肺组织学和鼻内免疫来比较宿主对这两种感染的反应。