口腔扁平苔藓中朗格汉斯细胞CD1a的表达——一项回顾性分析
Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis.
作者信息
Kulkarni Ganesh, Sakki Esther Priyadarshini, Kumar Yennavaram Vijay, Kolimi Sadananda, Perika Ravi, Karthik Kalepu Venkata, Kumar Kandukuri Mahesh, Kalyan Venumbaka Siva
机构信息
Senior Lecturer, Department of Oral Pathology, Malla Reddy Institute of Dental Sciences , Hyderabad, Telangana, India .
Senior Lecturer, Department of Oral Pathology, Meghana Institute of Dental sciences , Nizamabad, Telangana, India .
出版信息
J Clin Diagn Res. 2016 Jun;10(6):ZC28-31. doi: 10.7860/JCDR/2016/19189.7966. Epub 2016 Jun 1.
INTRODUCTION
Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.
AIM
The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.
MATERIALS AND METHODS
A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.
RESULTS
LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).
CONCLUSION
The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.
引言
朗格汉斯细胞（LCs）是口腔上皮的树突状细胞，在从牙龈炎到口腔癌的一系列口腔病变中发挥作用。口腔扁平苔藓（OLP）是一种口腔黏膜T淋巴细胞介导的针对未知假定抗原或变应原的免疫反应。
目的
本研究的目的是量化OLP中未成熟LCs的存在，并与正常上皮进行比较。
材料与方法
进行了一项回顾性研究，使用了30例OLP病例。使用多克隆抗CD1a抗体进行免疫组织化学，以鉴定10例正常组织和30例OLP样本中的LCs。使用曼-惠特尼U检验分析LCs在病变组织和正常黏膜中的分布。
结果
与正常上皮相比，OLP中的LC群体显著更高（p<0.001）。
结论
LCs的增加表明其在OLP抗原检测及随后向T淋巴细胞呈递过程中发挥的积极作用。
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