Qi Ying, Martin Maureen P, Gao Xiaojiang, Jacobson Lisa, Goedert James J, Buchbinder Susan, Kirk Gregory D, O'Brien Stephen J, Trowsdale John, Carrington Mary
Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA.
PLoS Pathog. 2006 Aug;2(8):e79. doi: 10.1371/journal.ppat.0020079.
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
