Shimizu A, Tamura A, Ishikawa O
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Eur J Dermatol. 2006 Jul-Aug;16(4):439-42.
In 1948, Ackerman first coined the term "verrucous carcinoma" to describe a variant of well-differentiated squamous cell carcinomas of the oral cavity. Similar lesions of the skin, other mucosa or mucocutaneous regions were subsequently reported. To date, verrucous carcinoma has been considered to be a variant of well-differentiated squamous cell carcinoma, which sometimes shows invasive changes but rarely metastasizes. In this study, findings for 3 patients with verrucous carcinomas in which foci of invasive squamous cell carcinoma existed are presented. Furthermore, the clinical features of 9 patients with verrucous carcinoma of the skin observed in our hospital between 1990 and 2004 are summarized. Lesions were located on the face, trunk or extremities. Foci of invasive squamous cell carcinoma were found in 30% of verrucous carcinomas, almost equal to the reported rate of verrucous carcinoma in oral or penile regions. Verrucous carcinoma of the skin should be recognized as a unique subtype of in situ carcinomas, which show exophytic nodular growth and are potentially malignant.
1948年，阿克曼首次提出“疣状癌”这一术语，用于描述口腔高分化鳞状细胞癌的一种变体。随后报道了皮肤、其他黏膜或黏膜皮肤区域的类似病变。迄今为止，疣状癌一直被认为是高分化鳞状细胞癌的一种变体，有时会出现浸润性改变，但很少发生转移。在本研究中，报告了3例存在浸润性鳞状细胞癌灶的疣状癌患者的研究结果。此外，总结了1990年至2004年间在我院观察到的9例皮肤疣状癌患者的临床特征。病变位于面部、躯干或四肢。在30%的疣状癌中发现了浸润性鳞状细胞癌灶，这一比例几乎与口腔或阴茎部位疣状癌的报道发生率相当。皮肤疣状癌应被视为原位癌的一种独特亚型，其表现为外生性结节状生长，具有潜在恶性。
