Adorisio Rachele, De Luca Leonardo, Rossi Joseph, Gheorghiade Mihai
Department of Cardiology and Cardiac Surgery, Ospedale Bambino Gesù, Rome, Italy.
Heart Fail Rev. 2006 Jun;11(2):109-23. doi: 10.1007/s10741-006-9482-z.
Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The mainstay life-saving drugs are angiotensin-converting enzyme inhibitors and beta-blockers. Additional benefits are obtained when angiotensin-receptor blockers or aldosterone antagonists are added. Digitalis and/or diuretics are useful for symptom reduction. In addition, combination therapy with hydralazine and isosorbide dinitrate is recommended in African Americans.
在西方世界，心力衰竭（HF）与高发病率和死亡率相关。在过去20年里，我们对其流行病学、病理生理学及治疗的认识有了显著提高。就目前而言，药物治疗是预防和对症策略的结合。主要的救命药物是血管紧张素转换酶抑制剂和β受体阻滞剂。添加血管紧张素受体阻滞剂或醛固酮拮抗剂可获得额外益处。洋地黄和/或利尿剂有助于减轻症状。此外，推荐非裔美国人使用肼屈嗪和硝酸异山梨酯联合治疗。
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