用于制备靶向特异性金纳米颗粒的纳米相容性化学
Nanocompatible chemistry toward fabrication of target-specific gold nanoparticles.
作者信息
Kannan Raghuraman, Rahing Valerie, Cutler Cathy, Pandrapragada Ravi, Katti Kavita K, Kattumuri Vijaya, Robertson J David, Casteel Stan J, Jurisson Silvia, Smith Charles, Boote Evan, Katti Kattesh V
机构信息
Department of Radiology, University of Missouri-Columbia, Columbia, Missouri 65212, USA.
出版信息
J Am Chem Soc. 2006 Sep 6;128(35):11342-3. doi: 10.1021/ja063280c.
Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as a reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization of gold nanoparticles by the edible gum arabic matrix has provided an effective pathway toward in vivo stable target-specific gold nanoparticles.
利用新型无毒膦基氨基酸作为还原剂的纳米相容化学，已在生物良性介质下促成了具有治疗用途的金纳米颗粒的研发。通过可食用阿拉伯胶基质对金纳米颗粒进行稳定化处理，为实现体内稳定的靶向特异性金纳米颗粒提供了一条有效途径。
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