Kumar V L, Wadhwa S N, Kumar V, Farooq A
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
J Surg Oncol. 1990 Jun;44(2):122-8. doi: 10.1002/jso.2930440213.
Cytosolic and nuclear androgen, estrogen and progesterone receptor content was measured in the groups of 11 prostatic carcinoma (PCA) and 32 benign prostatic hypertrophy (BPH) samples. All BPH cases were positive for the cytosolic progesterone (PRc) and estrogen receptor (ERc), whereas only 85% of cases (23/27) contained the androgen receptor (ARc). Only those five patients who received estrogen treatment in the PCA group had detectable ARc. PRc was present in all of the PCA cases, whereas ERc could be detected in only 82% (9/11) of cases. Cytosolic contents of all three steroid receptors, however, were higher in the PCA group. The level of nuclear steroid receptors, although present in fewer cases in both groups, was higher than the cytoplasmic receptors. The serum profile of estradiol, cortisol, and prolactin was normal in both groups, whereas LH, FSH, and progesterone levels were higher than in normal adults. Serum testosterone level was within normal range in the BPH group, but it was significantly below normal (P less than 0.005) in PCA patients.
对11例前列腺癌（PCA）样本组和32例良性前列腺增生（BPH）样本组的细胞溶质及细胞核雄激素、雌激素和孕激素受体含量进行了测定。所有BPH病例的细胞溶质孕激素（PRc）和雌激素受体（ERc）均呈阳性，而只有85%的病例（23/27）含有雄激素受体（ARc）。PCA组中仅5例接受雌激素治疗的患者可检测到ARc。所有PCA病例均存在PRc，而仅82%（9/11）的病例可检测到ERc。然而，PCA组中所有三种甾体受体的细胞溶质含量均较高。两组中细胞核甾体受体的病例数较少，但其含量高于细胞质受体。两组的雌二醇、皮质醇和催乳素血清水平均正常，而促黄体生成素（LH）、促卵泡生成素（FSH）和孕激素水平高于正常成年人。BPH组的血清睾酮水平在正常范围内，但PCA患者的血清睾酮水平显著低于正常水平（P<0.005）。
