急性和长期住院老年患者血清锌、白蛋白、α-2-巨球蛋白和转铁蛋白水平的研究。
A study of serum zinc, albumin, alpha-2-macroglobulin and transferrin levels in acute and long stay elderly hospital patients.
作者信息
Craig G M, Evans S J, Brayshaw B J, Raina S K
机构信息
Department of Geriatric Medicine, General Hospital, Northampton, UK.
出版信息
Postgrad Med J. 1990 Mar;66(773):205-9. doi: 10.1136/pgmj.66.773.205.
Serum zinc levels measured by atomic absorption spectrophotometry were found to be low (less than 10.5 mumols/l) in 38% of acute geriatric admissions, 69% of long stay geriatric patients and 19% of a control group of elderly hospital patients with a normal serum albumin. There was a significant positive correlation between serum zinc and serum albumin in all groups. In acutely ill geriatric patients only, there was a weak but statistically significant positive correlation between serum zinc and alpha-2-macroglobulin (A2M) (r = 0.20), P less than 0.05). Serum transferrin was low in 46% of acute geriatric patients and 22% of long stay geriatric patients but there was no correlation between serum zinc and serum transferrin levels in any patient group. There were significant differences in serum zinc, A2M and transferrin levels between the acute and long stay geriatric patients. The differences in serum zinc levels between these patients groups could not be explained by changes in serum A2M, transferrin or albumin. Changes mediated by an acute phase response may have influenced results in the acute geriatric group of patients.
通过原子吸收分光光度法测定血清锌水平，结果发现，在急性老年住院患者中，38%的患者血清锌水平较低（低于10.5微摩尔/升）；在长期住院的老年患者中，这一比例为69%；而在血清白蛋白正常的老年医院对照患者组中，该比例为19%。所有组中血清锌与血清白蛋白之间均存在显著的正相关。仅在急性病老年患者中，血清锌与α-2-巨球蛋白（A2M）之间存在微弱但具有统计学意义的正相关（r = 0.20，P<0.05）。46%的急性老年患者和22%的长期住院老年患者血清转铁蛋白水平较低，但在任何患者组中血清锌与血清转铁蛋白水平之间均无相关性。急性老年患者和长期住院老年患者在血清锌、A2M和转铁蛋白水平上存在显著差异。这些患者组之间血清锌水平的差异无法用血清A2M、转铁蛋白或白蛋白的变化来解释。急性期反应介导的变化可能影响了急性老年患者组的结果。
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