Odink J, Van der Ploeg H M, Van den Berg H, Van Kempen G M, Bruinse H W, Louwerse E S
Department of Clinical Biochemistry, TNO-CIVO Toxicology and Nutrition Institute, Zeist, Netherlands.
Psychosom Med. 1990 May-Jun;52(3):346-56. doi: 10.1097/00006842-199005000-00008.
Circadian and circatrigintan (menstrual) rhythms in biogenic amines were studied in premenstrual syndrome (PMS). Selection of patients and controls was based on assessment of Menstrual Distress Questionnaires (MDQs). Patients showed a clear increase in menstral tension symptoms in the week before menstruation, both during selection and during the study. In the group of control subjects, there was hardly any increase in average MDQ symptoms during the late luteal phase. Diurnal urine and nocturnal urine were collected on days 5, 11, 17, 21, and 25 of the cycle. Blood was sampled from subjects in supine position through an intravenous (iv) catheter the morning after urine collection. Patients showed a higher tryptophan (Trp) and epinephrine (Epi) level in plasma, higher excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) in urine and a larger volume of 24-hr urine. Excretion of norepinephrine (NE) in 24-hr urine showed a linear increase during the cycle, while excretion of dopamine (DA) showed a quadratic pattern, being lowest at day 17. Homovanillic acid (HVA) and MHPG gave cubic patterns, i.e., an increase during the follicular phase, followed by a decrease after ovulation and a subsequent increase in the late luteal phase. Plasma Epi showed a linear decline during the cycle in patients, but not in control subjects. Excretion of NE, Epi, vanilmandelic acid (VMA), and HVA in urine was higher during the day than at night. The results of this study suggest that the metabolism of biogenic amines in patients suffering from PMS differs from that in control subjects, but that, except for plasma Epi, changes do not parallel the actual presence of PMS symptoms.
对经前综合征（PMS）患者生物胺的昼夜节律和月经周期节律进行了研究。患者和对照的选择基于月经困扰问卷（MDQ）评估。在选择过程和研究期间，患者在月经前一周经前紧张症状均明显增加。在对照组中，黄体晚期MDQ症状平均几乎没有增加。在月经周期的第5、11、17、21和25天收集白天尿液和夜间尿液。在收集尿液后的次日早晨，通过静脉导管从仰卧位的受试者采集血液。患者血浆中色氨酸（Trp）和肾上腺素（Epi）水平较高，尿中3-甲氧基-4-羟基苯乙二醇（MHPG）排泄量较高，24小时尿量较大。24小时尿中去甲肾上腺素（NE）排泄量在整个周期呈线性增加，而多巴胺（DA）排泄量呈二次曲线模式，在第17天最低。高香草酸（HVA）和MHPG呈三次曲线模式，即在卵泡期增加，排卵后下降，随后在黄体晚期再次增加。患者血浆Epi在整个周期呈线性下降，而对照组则无此现象。尿液中NE、Epi、香草扁桃酸（VMA）和HVA的排泄量白天高于夜间。本研究结果表明，PMS患者生物胺的代谢与对照组不同，但除血浆Epi外，变化与PMS症状的实际出现并不平行。
