Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D, Brennan P, O'Brien R
Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver.
Science. 1990 Jul 6;249(4964):67-9. doi: 10.1126/science.1695022.
Small synthetic peptides that correspond to different portions of the 65-kilodalton mycobacterial heat shock protein (Hsp65) were used to identify a putative antigenic epitope for gamma delta cells. Weaker gamma delta responses to the equivalent portion of the autologous homolog, mouse Hsp63, were also seen. The stimulatory epitope overlaps with an epitope recognized by arthritogenic alpha beta T cell clones. The data suggest that gamma delta cells have a role in autoimmune disorders and imply that these cells recognize ligands by a mechanism similar to that of alpha beta T lymphocytes, that is, in the form of small processed protein fragments bound to antigen-presenting molecules.
对应于65千道尔顿分枝杆菌热休克蛋白（Hsp65）不同部分的小合成肽被用于鉴定γδ细胞的假定抗原表位。对自体同源物小鼠Hsp63的等效部分也观察到较弱的γδ反应。刺激表位与致关节炎的αβT细胞克隆识别的表位重叠。数据表明γδ细胞在自身免疫性疾病中起作用，并暗示这些细胞通过与αβT淋巴细胞类似的机制识别配体，即以与抗原呈递分子结合的小加工蛋白片段的形式。
