Transplantation Research Immunology Group, University of Oxford, Oxford, United Kingdom.
Transplantation. 2018 Dec;102(12):1983-1993. doi: 10.1097/TP.0000000000002335.
γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.
γδ T 细胞是一群表达异二聚体 T 细胞受体的淋巴细胞，该受体由 γ 和 δ 链组成。它们在形态和功能上具有异质性，具有先天适应性行为，并表现出广泛的免疫监视、免疫调节和直接细胞毒性等多种活性。γδ T 细胞对同种异体移植物的具体反应尚未完全阐明，在不同情况下，其作用既有有害的，也有耐受的。本文概述了 γδ T 细胞的相关文献，探讨了其功能异质性对移植后结果的影响，并思考了利用其有益特性的方法。
