Keene Sarah, Sarao Manbeer S, McDonald Philip J, Veltman Jennifer
Department of Internal Medicine, Wayne State University, Detroit, MI, USA.
Armed Forces Medical College, Pune, Maharashtra, India.
Access Microbiol. 2019 Mar 20;1(1):e000001. doi: 10.1099/acmi.0.000001. eCollection 2019.
is a saprophytic yeast known to colonize the human skin, respiratory tract and gastrointestinal tract. It can cause local or disseminated disease (geotrichosis), mainly in the immunocompromised host. Trauma, indwelling catheter use, prolonged broad-spectrum antibiotic treatment and critical illness have also been implicated as risk factors. Here we report the first case, to our knowledge, of cutaneous infection in a burn patient. The isolate had a high amphotericin B minimum inhibitory concentration (MIC) and the patient experienced concomitant fungaemia, and so was treated with a combination of voriconazole and micafungin. This case highlights the importance of source control, rapid identification of infection and MIC determination to guide antifungal therapy, which typically consists of amphotericin B with or without flucytosine or voriconazole alone. Clinicians should be aware of geotrichosis as a clinical entity in burn patients as well as in the immunocompromised. Antifungal resistance and breakthrough disease are an ongoing concern due to the increasing number of immunocompromised at-risk patients and the use of routine mould prophylaxis.
是一种腐生酵母,已知可定殖于人体皮肤、呼吸道和胃肠道。它可引起局部或播散性疾病(地霉病),主要发生在免疫功能低下的宿主中。创伤、留置导管的使用、长期广谱抗生素治疗和危重病也被认为是危险因素。据我们所知,本文报告了首例烧伤患者皮肤感染病例。分离株对两性霉素B的最低抑菌浓度(MIC)较高,且患者同时发生真菌血症,因此采用伏立康唑和米卡芬净联合治疗。该病例强调了源头控制、快速识别感染以及测定MIC以指导抗真菌治疗的重要性,抗真菌治疗通常包括含或不含氟胞嘧啶的两性霉素B或单独使用伏立康唑。临床医生应意识到地霉病在烧伤患者以及免疫功能低下患者中是一种临床实体。由于免疫功能低下的高危患者数量不断增加以及常规霉菌预防措施的使用,抗真菌耐药性和突破性疾病一直是令人担忧的问题。