Leleu Xavier, O'Connor Kelly, Ho Allen W, Santos Daniel D, Manning Robert, Xu Lian, Hatjiharissi Evdoxia, Moreau Anne-Sophie, Branagan Andrew R, Hunter Zachary R, Dimmock Elizabeth A, Soumerai Jacob, Patterson Christopher, Ghobrial Irene, Treon Steven P
Bing Center for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Am J Hematol. 2007 Jan;82(1):83-4. doi: 10.1002/ajh.20724.
While a familial predisposition may exist in up to 20% of patients with Waldenström's Macroglobulinemia (WM), the precipitating cause of this B-cell malignancy remains unknown in most patients. In previous studies, an association between hepatitis C virus (HCV) infection and WM has been suggested as etiological. This relationship has been the subject of debate, however, with some studies demonstrating increased incidence of HCV infection among WM patients and other studies showing no such association exists. This discordance might be attributable to the analytical method used, HCV antibody detection, which might be ineffective in patients with immunosuppression. We therefore analyzed the prevalence of HCV in a large population of WM patients utilizing both an HCV antibody detection immunoassay as well as qualitative polymerase chain reaction assay to directly detect HCV presence in serum samples. None of 100 randomly tested WM patients in this study tested positive for HCV by either analytical method. Our results therefore demonstrate a lack of association between HCV and WM.
虽然高达20%的华氏巨球蛋白血症（WM）患者可能存在家族易感性，但在大多数患者中，这种B细胞恶性肿瘤的诱发原因仍然未知。在先前的研究中，丙型肝炎病毒（HCV）感染与WM之间的关联被认为是病因。然而，这种关系一直存在争议，一些研究表明WM患者中HCV感染的发生率增加，而其他研究则表明不存在这种关联。这种不一致可能归因于所使用的分析方法，即HCV抗体检测，这种方法在免疫抑制患者中可能无效。因此，我们使用HCV抗体检测免疫测定法以及定性聚合酶链反应测定法，对大量WM患者的HCV流行情况进行了分析，以直接检测血清样本中HCV的存在。在本研究中，随机检测的100名WM患者中，通过任何一种分析方法检测HCV均为阴性。因此，我们的结果表明HCV与WM之间不存在关联。
