Izumi T, Sasaki R, Tsunoda S, Akutsu M, Okamoto H, Miura Y
Department of Medicine, Jichi Medical School, Japan.
Leukemia. 1997 Apr;11 Suppl 3:516-8.
Italian authors report that hepatitis C virus (HCV) infection may be one of the causes of lymphoid malignancy such as non-Hodgkin's lymphoma (NHL) and Waldenström's macroglobulinemia (WM). To assess the relationship between HCV infection and B cell malignancy (BCM) in Japan, we analyzed HCV-RNA in 50 patients with BCM [25 cases of NHL, 4 of WM and 21 of multiple myeloma (MM)] and determined genotype of infected HCV(Okamoto's classification) using reverse transcription-polymerase chain reaction assay. Eight (16.0%) of 50 patients with BCM were HCV-RNA positive [HCV(+)], while no patients were HCV(+) in control group (18 patients of non-B cell NHL). Numbers of HCV(+) cases in each group examined were as follows; four (16.0%) in B cell NHL (genotype II/III/IV were 3/1/0, respectively), one (25.0%) in WM (genotype III) and three (14.3%) in MM (genotype II/III/IV were 1/1/1, respectively). All patients examined had no symptoms and signs suggesting vasculitis. The incidence of HCV infection in the patients with BCM was markedly higher than that (approximately 1%) of healthy blood donors in Japan. We also experienced four B cell NHL cases with splenic or hepatic origin in the course of chronic hepatitis C. These results implicate the association between persistent HCV infection and the occurrence of BCM.
意大利的作者报告称，丙型肝炎病毒（HCV）感染可能是非霍奇金淋巴瘤（NHL）和华氏巨球蛋白血症（WM）等淋巴系统恶性肿瘤的病因之一。为评估日本HCV感染与B细胞恶性肿瘤（BCM）之间的关系，我们分析了50例BCM患者（25例NHL、4例WM和21例多发性骨髓瘤（MM））的HCV-RNA，并使用逆转录聚合酶链反应法确定了感染HCV的基因型（冈本分类法）。50例BCM患者中有8例（16.0%）HCV-RNA呈阳性[HCV(+)]，而对照组（18例非B细胞NHL患者）中无HCV(+)患者。各检查组中HCV(+)病例数如下：B细胞NHL组4例（16.0%）（基因型II/III/IV分别为3/1/0），WM组1例（25.0%）（基因型III），MM组3例（14.3%）（基因型II/III/IV分别为1/1/1）。所有受检患者均无提示血管炎的症状和体征。BCM患者中HCV感染的发生率明显高于日本健康献血者的发生率（约1%）。我们还遇到了4例慢性丙型肝炎病程中起源于脾脏或肝脏的B细胞NHL病例。这些结果提示持续的HCV感染与BCM的发生之间存在关联。
