Grant Jon E, Correia Stephen, Brennan-Krohn Thea
Butler Hospital/Brown Medical School, Providence, RI 02906, USA.
Psychiatry Res. 2006 Oct 30;147(2-3):233-7. doi: 10.1016/j.pscychresns.2006.03.003. Epub 2006 Sep 7.
This study's goal was to examine microstructural organization of frontal white matter in kleptomania. Ten females with DSM-IV kleptomania and 10 female controls underwent diffusion tensor imaging. Inferior frontal white matter was the a priori region of interest. Trace and fractional anisotropy (FA) were also calculated for frontal and posterior cortical regions in both subject groups. Kleptomania subjects had significantly higher mean frontal Trace, and significantly lower mean frontal FA than control subjects. Group differences remained significant when right and left frontal Trace and FA were analyzed. Groups did not differ significantly in posterior Trace or FA. Kleptomania may be associated with decreased white matter microstructural integrity in inferior frontal brain regions.
本研究的目的是检查偷窃癖患者额叶白质的微观结构组织。10名符合《精神疾病诊断与统计手册》第四版(DSM-IV)偷窃癖诊断标准的女性和10名女性对照者接受了扩散张量成像检查。额下回白质是预先设定的感兴趣区域。还计算了两组受试者额叶和后皮质区域的轨迹值和分数各向异性(FA)。与对照者相比,偷窃癖患者的额叶平均轨迹值显著更高,而额叶平均FA值显著更低。当分别分析左右额叶的轨迹值和FA值时,两组之间的差异仍然显著。两组在后皮质区域的轨迹值或FA值方面没有显著差异。偷窃癖可能与额叶下部脑区白质微观结构完整性降低有关。