Tani E, Senba E, Kokumai S, Masuyama K, Ishikawa T, Tohyama M
Department of Otorhinolaryngology, Kumamoto University, School of Medicine, Japan.
Neurosci Lett. 1990 Apr 20;112(1):1-6. doi: 10.1016/0304-3940(90)90312-w.
Short-term effects of application of histamine to the nasal mucosa on trigeminal ganglion neurons containing calcitonin gene-related peptide (CGRP) and substance P (SP) were examined in guinea pig. Immunoreactivities to CGRP and SP in these neurons were decreased 30 min after the histamine application. The decreases were most marked at 1-3 h after application, after which the immunoreactivities began to increase, reaching the base line by 6 h after the application. The immunoreactivities to CGRP and SP in the nerve endings of nasal mucosa were not decreased. The expression of mRNAs for both peptides in the soma of trigeminal neurons was unchanged. The histamine application to the nasal mucosa may cause release of CGRP and SP from terminals of peripheral processes of trigeminal ganglion neurons, and enhance axonal transport of these peptides, but does not affect their biosynthesis in the soma of trigeminal ganglion neurons.
在豚鼠中研究了将组胺应用于鼻黏膜对含有降钙素基因相关肽（CGRP）和P物质（SP）的三叉神经节神经元的短期影响。组胺应用30分钟后，这些神经元中CGRP和SP的免疫反应性降低。在应用后1 - 3小时降低最为明显，之后免疫反应性开始增加，在应用后6小时达到基线。鼻黏膜神经末梢中CGRP和SP的免疫反应性未降低。三叉神经元胞体中两种肽的mRNA表达未改变。将组胺应用于鼻黏膜可能会导致三叉神经节神经元外周突末梢释放CGRP和SP，并增强这些肽的轴突运输，但不影响它们在三叉神经节神经元胞体中的生物合成。
