Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Italy.
Br J Pharmacol. 2013 Sep;170(1):38-45. doi: 10.1111/bph.12266.
The term 'neurogenic inflammation' has been adopted to describe the local release of inflammatory mediators, such as substance P and calcitonin gene-related peptide, from neurons. Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. The aim of this review is to summarize the most recent findings on the role of histamine in neurogenic inflammation, with particular regard to nociceptive pain, as well as neurogenic inflammation in the skin, airways and bladder.
“神经源性炎症”这一术语被用来描述神经递质（如 P 物质和降钙素基因相关肽）从神经元中的局部释放。一旦释放，这些神经肽就会诱导相邻肥大细胞释放组胺。反过来，组胺又会引起 P 物质和降钙素基因相关肽的释放；因此，在神经源性炎症中建立了组胺和神经肽之间的双向联系。本综述的目的是总结组胺在神经源性炎症中的作用的最新发现，特别关注伤害性疼痛以及皮肤、气道和膀胱中的神经源性炎症。
