Zurita Raül, Puiggalí Jordi, Rodríguez-Galán Alfonso
Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, E-08028, Barcelona, Spain.
Macromol Biosci. 2006 Sep 15;6(9):767-75. doi: 10.1002/mabi.200600084.
The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a Sörensen's medium at 37 degrees C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(p-dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, epsilon-caprolactone and trimethylene carbonate (PLA/PCA/PTMC 10/60/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred.
考虑制备含有布洛芬作为抗炎剂的单丝和复丝缝线。聚对二氧环己酮单丝样品可以通过使用诸如二氯甲烷之类的溶胀剂的分子扩散过程来负载。已经测量了力学性能，并且在结拉伸试验中，负载布洛芬的样品未显示出显著变化。研究了在37℃的索伦森介质中的负载过程和释放的动力学。还从含有布洛芬的薄膜和平板聚对二氧环己酮样品估计了扩散系数，并将它们的释放行为与单丝的释放行为进行了比较。还研究了基于丙交酯、ε-己内酯和三亚甲基碳酸酯（PLA/PCA/PTMC 10/60/30）的涂层共聚物的释放。这种涂层能很好地溶解布洛芬分子，可用于编织缝线或当优选快速剂量的布洛芬时使用。
