病毒衣壳中的量子点封装。

Quantum dot encapsulation in viral capsids.

作者信息

Dixit Suraj K, Goicochea Nancy L, Daniel Marie-Christine, Murali Ayaluru, Bronstein Lyudmila, De Mrinmoy, Stein Barry, Rotello Vincent M, Kao C Cheng, Dragnea Bogdan

机构信息

Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.

出版信息

Nano Lett. 2006 Sep;6(9):1993-9. doi: 10.1021/nl061165u.

DOI:10.1021/nl061165u

PMID:16968014

Abstract

Incorporation of CdSe/ZnS semiconductor quantum dots (QDs) into viral particles provides a new paradigm for the design of intracellular microscopic probes and vectors. Several strategies for the incorporation of QDs into viral capsids were explored; those functionalized with poly(ethylene glycol) (PEG) can be self-assembled into viral particles with minimal release of photoreaction products and enhanced stability against prolonged irradiation.

摘要

将CdSe/ZnS半导体量子点（QDs）掺入病毒颗粒为细胞内微观探针和载体的设计提供了一种新范例。人们探索了几种将量子点掺入病毒衣壳的策略；那些用聚乙二醇（PEG）功能化的量子点可以自组装成病毒颗粒，光反应产物释放极少，并且对长时间照射的稳定性增强。