Alviggi L, Johnston C, Hoskins P J, Tee D E, Pyke D A, Leslie R D, Vergani D
Lancet. 1984 Jul 7;2(8393):4-6. doi: 10.1016/s0140-6736(84)91994-9.
Expression of HLA DR antigens on T lymphocytes indicates that these cells are actively involved in an immune response. Raised levels of activated T lymphocytes were found in 14 of 15 recently diagnosed but in only 7 of 28 long-standing insulin-dependent diabetics. 9 of the recently diagnosed patients retested 6 months later still had high levels of activated T lymphocytes. Even long-standing insulin-dependent diabetics had significantly higher levels of activated T lymphocytes than non-insulin-dependent diabetics and healthy controls. 5 of 7 unaffected co-twins of recently diagnosed insulin-dependent diabetics had high levels of activated T cells; this increase persisted in 2 retested 6 months later, when mildly impaired glucose tolerance had developed. These results confirm that there is an active cellular immune reaction in newly diagnosed insulin-dependent diabetics which may precede the disease and persist for at least 6 months after its appearance.
T淋巴细胞上HLA DR抗原的表达表明这些细胞积极参与免疫反应。在15名新诊断的患者中，有14名发现活化T淋巴细胞水平升高，但在28名长期胰岛素依赖型糖尿病患者中只有7名如此。9名新诊断的患者在6个月后重新检测时，活化T淋巴细胞水平仍然很高。即使是长期胰岛素依赖型糖尿病患者，其活化T淋巴细胞水平也明显高于非胰岛素依赖型糖尿病患者和健康对照者。7名新诊断的胰岛素依赖型糖尿病患者未受影响的同卵双胞胎中有5名活化T细胞水平较高；6个月后重新检测时，其中2名的这种升高情况仍然存在，此时已出现轻度糖耐量受损。这些结果证实，新诊断的胰岛素依赖型糖尿病患者存在活跃的细胞免疫反应，这种反应可能在疾病之前出现，并在疾病出现后至少持续6个月。
