Okada Mineyuki, Yamashita Yasutaka, Oseto Mitsuaki, Ogawa Tomoko, Kaiho Ikuo, Shinozaki Kuniko
Division of Virology, Chiba Prefectural Institute of Public Health, Chiba-shi, Chiba 260-8715, Japan.
Virus Genes. 2006 Oct;33(2):157-61. doi: 10.1007/s11262-005-0051-7.
Sapovirus (SV), which causes gastroenteritis in humans, is composed of genetically divergent viruses classified into 5 genogroups. In this study, 2.2-kb nucleotide sequences of the 3' terminus of the genome of 15 SV strains detected in Japan were determined. The 15 SV strains could be classified into four genogroups (GI, GII, GIV and GV), and in two of these, GI and GII, 10 genotypes were identified. The amino acid sequences of the central variable region of the capsid protein showed less than 81% identity when strains belonging to different genotypes were compared. It was therefore supposed that antigenic variety exists between different genotypes. These results will be useful for further genetic and antigenic analyses of SV.
札幌病毒（SV）可导致人类肠胃炎，由基因上不同的病毒组成，分为5个基因组。在本研究中，测定了在日本检测到的15株SV病毒株基因组3'末端的2.2 kb核苷酸序列。这15株SV病毒株可分为4个基因组（GI、GII、GIV和GV），其中GI和GII这两个基因组中鉴定出了10种基因型。当比较不同基因型的病毒株时，衣壳蛋白中央可变区的氨基酸序列同一性低于81%。因此推测不同基因型之间存在抗原多样性。这些结果将有助于对SV进行进一步的遗传和抗原分析。
