McNicol P J, Dodd J G
Cadham Provincial Laboratory, Winnipeg, Man., Canada.
Can J Microbiol. 1990 May;36(5):359-62. doi: 10.1139/m90-062.
Human papillomavirus deoxyribonucleic acid was detected in prostate tissue from patients with benign prostatic hyperplasia or prostatic carcinoma. Radiolabelled genomic probes, specific for the sexually transmitted human papillomavirus types 16 and 18, were used to detect viral genomic sequences in prostate DNA samples analyzed by the Southern blot technique. Viral sequences were identified in DNA from 7 of 16 prostate samples including both hyperplastic and carcinoma tissues and including tissues obtained by transurethral resection or suprapubic prostatectomy. These data indicate that the prostate gland can be infected with human papillomavirus and imply that the prostate may act as a reservoir for the sexual transmission of papillomavirus via seminal fluid. The detection of both episomal and integrated viral DNA sequences in prostate tissue may have important implications for the etiology of prostate disease.
在良性前列腺增生或前列腺癌患者的前列腺组织中检测到了人乳头瘤病毒脱氧核糖核酸。使用针对性传播的16型和18型人乳头瘤病毒的放射性标记基因组探针，通过Southern印迹技术检测前列腺DNA样本中的病毒基因组序列。在16个前列腺样本中的7个样本的DNA中鉴定出病毒序列，这些样本包括增生组织和癌组织，以及经尿道切除术或耻骨上前列腺切除术获得的组织。这些数据表明前列腺可被人乳头瘤病毒感染，并暗示前列腺可能作为乳头瘤病毒通过精液进行性传播的储存库。在前列腺组织中检测到游离型和整合型病毒DNA序列可能对前列腺疾病的病因学具有重要意义。
