McNicol P J, Dodd J G
Cadham Provincial Laboratory, Winnipeg, Manitoba, Canada.
J Urol. 1991 Apr;145(4):850-3. doi: 10.1016/s0022-5347(17)38476-8.
Specific human papillomavirus (HPV) types are associated with benign and malignant lesions of the anogenital region including the prostate gland. Using polymerase chain reaction (PCR) amplification of type-specific HPV sequences, we have assessed the prevalence of HPV DNA in prostate tissue from 88 individuals. Amplified sequences specific for HPV 16 were found in 34 of 56 benign prostatic hyperplasias and in 14 of 27 prostatic carcinomas. In contrast, HPV 18 was identified in only three benign hyperplasias and one carcinoma, all of which also contained HPV 16 DNA. Four of five normal prostates obtained at autopsy had no detectable HPV infection; one contained HPV 16 sequences. No significant difference in the prevalence of HPV DNA is observed between patients with benign disease and those with evidence of malignancy when fragments of surgical material are analyzed. Surgical method (transurethral resection or suprapubic prostatectomy) had no effect on the frequency of HPV detection. The prevalence of HPV DNA in the small number of normal prostates analyzed was not significantly different from that in the surgical samples. The presence of HPV in prostate tissues suggests a possible reservoir for sexual transmission of types with oncogenic potential. A role for the virus in the etiology of prostatic neoplasia remains to be demonstrated.
特定的人乳头瘤病毒（HPV）类型与包括前列腺在内的肛门生殖器区域的良性和恶性病变相关。通过聚合酶链反应（PCR）扩增型特异性HPV序列，我们评估了88例个体前列腺组织中HPV DNA的流行情况。在56例良性前列腺增生症中的34例以及27例前列腺癌中的14例中发现了HPV 16的特异性扩增序列。相比之下，仅在3例良性增生症和1例癌中鉴定出HPV 18，所有这些病例也都含有HPV 16 DNA。在尸检获得的5例正常前列腺中，有4例未检测到HPV感染；1例含有HPV 16序列。当分析手术材料片段时，良性疾病患者和有恶性证据的患者之间HPV DNA的流行率没有显著差异。手术方法（经尿道切除术或耻骨上前列腺切除术）对HPV检测频率没有影响。分析的少数正常前列腺中HPV DNA的流行率与手术样本中的流行率没有显著差异。前列腺组织中HPV的存在表明可能存在具有致癌潜力的HPV类型的性传播储存库。该病毒在前列腺肿瘤发生病因中的作用仍有待证实。
