Fox J D, Briggs M, Ward P A, Tedder R S
Department of Medical Microbiology, University College and Middlesex School of Medicine, London.
Lancet. 1990 Sep 8;336(8715):590-3. doi: 10.1016/0140-6736(90)93392-3.
In an investigation of the role of saliva in the transmission of human herpesvirus 6 (HHV6) sections of salivary gland tissue were screened for HHV6-specific DNA by in-situ hybridisation and for HHV6-specific protein by immunohistochemical staining with monoclonal antibodies against the virus. All of nine submandibular glands and one of four parotid glands showed the presence of HHV6 genome and expressed protein by these techniques. The findings are consistent with transmission of HHV6 by saliva and suggest that salivary gland tissue is a site of replication of the virus and a potential site for HHV6 persistence.
在一项关于唾液在人类疱疹病毒6型（HHV6）传播中作用的调查中，通过原位杂交对唾液腺组织切片进行HHV6特异性DNA筛查，并使用针对该病毒的单克隆抗体通过免疫组织化学染色检测HHV6特异性蛋白。九个下颌下腺中的所有样本以及四个腮腺中的一个样本通过这些技术均显示存在HHV6基因组并表达了蛋白。这些发现与HHV6通过唾液传播一致，并表明唾液腺组织是该病毒的复制位点以及HHV6持续存在的潜在位点。
