Martínez-Aldave Alejandro, Gutiérrez Tapia Gissella
División de Ortodoncia, Universidad Científica del Sur. Lima, Perú.
Rev Cient Odontol (Lima). 2024 Sep 17;12(3):e211. doi: 10.21142/2523-2754-1203-2024-211. eCollection 2024 Jul-Sep.
The search to optimize tooth movement and reduce treatment time is of great interest to the orthodontist, as it involves innovating new materials and procedures to achieve the treatment objectives in the short term. The administration of prostaglandins has been studied, and their effect on accelerating tooth movement when administered locally has been proven. The objective of this study was to evaluate the latest achievements concerning the effects of local administration of prostaglandins to accelerate tooth movement for orthodontic purposes.
A search was conducted in four databases (PubMed, SciELO, Cochrane, Google Scholar) and three specialized journals (AJODO, Angle Orthodontics, Journal of Clinical Orthodontics) until August 2023. The methodological quality of the studies was analyzed using the PRISMA checklist.
The study had 14 articles. Local administration of prostaglandins accelerates the speed of tooth movement and increases the number of osteoclasts. Evidence of root resorption has been reported concerning high doses of prostaglandins via the submucosal route and a reduction in root resorption by administering prostaglandins with calcium gluconate. Local administration of prostaglandins via the submucosal route produces mild to moderate pain, and inoculation with a local anesthetic is recommended. However, oral administration of the analogous compound Misoprostol does not produce pain or evidence of root resorption.
Sufficient scientific evidence has not been found to support the local administration of prostaglandins as a safe method to accelerate tooth movement in humans.
寻求优化牙齿移动并缩短治疗时间是正畸医生非常感兴趣的事情，因为这涉及创新新材料和程序以在短期内实现治疗目标。人们已经对前列腺素的给药进行了研究，并且已经证实其局部给药对加速牙齿移动的效果。本研究的目的是评估局部应用前列腺素以加速正畸牙齿移动的效果方面的最新成果。
截至2023年8月，在四个数据库（PubMed、SciELO、Cochrane、谷歌学术）和三本专业期刊（《美国正畸与牙颌面矫形杂志》《安格尔正畸学杂志》《临床正畸学杂志》）中进行了检索。使用PRISMA清单分析研究的方法学质量。
该研究纳入了14篇文章。局部应用前列腺素可加快牙齿移动速度并增加破骨细胞数量。有报告称，通过黏膜下途径给予高剂量前列腺素会出现牙根吸收的证据，而将前列腺素与葡萄糖酸钙联合给药可减少牙根吸收。通过黏膜下途径局部应用前列腺素会产生轻度至中度疼痛，建议注射局部麻醉剂。然而，口服类似化合物米索前列醇不会产生疼痛或牙根吸收的证据。
尚未找到足够的科学证据支持将局部应用前列腺素作为加速人类牙齿移动的安全方法。
