Brigido Stephen A
Foot and Ankle Center at Coordinated Health, East Stroudsburg, PA, USA.
Int Wound J. 2006 Sep;3(3):181-7. doi: 10.1111/j.1742-481X.2006.00209.x.
A prospective, single-centre, randomized controlled study was performed to evaluate the effectiveness of Graftjacket, a human acellular regenerative tissue matrix as a treatment option for chronic non healing lower extremity wounds. Twenty-eight diabetic patients with full-thickness wounds that had been present for at least 6 weeks were treated with sharp debridement and randomized to a single application of Graftjacket tissue matrix plus mineral oil-soaked fluff compression dressing or to a control treatment of wound gel with gauze dressings. All patients were seen weekly. By week 16, 12 of 14 patients treated with Graftjacket tissue matrix demonstrated complete wound closure compared with 4 of 14 patients in the control group. Patients treated with Graftjacket tissue matrix showed a statistically significant higher percentage of wound healing with respect to wound area, and clinically significant differences in wound depth and wound volume. This comparison is not performed to demonstrate that the application of the Grafjacket is more effective than sharp debridement. This study is done to help assign a role to the use of Graftjacket matrix in lower extremity wound care.
进行了一项前瞻性、单中心、随机对照研究，以评估人脱细胞再生组织基质Graftjacket作为慢性不愈合下肢伤口治疗选择的有效性。28例患有全层伤口且已存在至少6周的糖尿病患者接受了锐性清创术，并随机分为单次应用Graftjacket组织基质加浸有矿物油的绒毛压缩敷料组或伤口凝胶加纱布敷料的对照治疗组。所有患者每周接受检查。到第16周时，接受Graftjacket组织基质治疗的14例患者中有12例伤口完全闭合，而对照组的14例患者中有4例伤口完全闭合。接受Graftjacket组织基质治疗的患者在伤口面积方面显示出统计学上显著更高的伤口愈合百分比，并且在伤口深度和伤口体积方面存在临床显著差异。进行这种比较并非为了证明应用Graftjacket比锐性清创术更有效。进行这项研究是为了帮助确定Graftjacket基质在下肢伤口护理中的作用。
