Brigido Stephen A, Boc Steven F, Lopez Ramon C
St. Agnes Medical Center, Philadelphia, Pa, USA.
Orthopedics. 2004 Jan;27(1 Suppl):s145-9. doi: 10.3928/0147-7447-20040102-14.
Wound healing is a significant problem in orthopedics. Graftjacket tissue matrix (Wright Medical Technology, Inc, Arlington, Tenn), a novel acellular regenerative tissue matrix, has been designed to aid wound closure. A prospective, randomized study was initiated to determine the efficacy of this tissue product in wound repair compared with conventional treatment. Lower extremity wounds are refractile to healing in patients with diabetes mellitus. Therefore, researchers used diabetic foot ulcers to evaluate the efficacy of GraftJacket tissue matrix in wound repair. Only a single administration of the tissue matrix was required. After 1 month of treatment, preliminary results demonstrate that this novel tissue matrix promotes faster healing at a statistically significant rate over conventional treatment. Because wounds in this series of patients are deep and circulation around the wound is poor, the preliminary results suggest that this tissue matrix will be applicable to other types of orthopedic wounds.
伤口愈合是骨科领域的一个重要问题。Graftjacket组织基质（Wright Medical Technology, Inc, Arlington, Tenn）是一种新型的无细胞再生组织基质，旨在辅助伤口闭合。一项前瞻性随机研究已启动，以确定该组织产品与传统治疗相比在伤口修复中的疗效。糖尿病患者的下肢伤口愈合困难。因此，研究人员使用糖尿病足溃疡来评估Graftjacket组织基质在伤口修复中的疗效。该组织基质只需单次施用。经过1个月的治疗，初步结果表明，与传统治疗相比，这种新型组织基质能以具有统计学意义的更快速度促进愈合。由于该系列患者的伤口较深且伤口周围血液循环较差，初步结果表明这种组织基质将适用于其他类型的骨科伤口。
