用于机会性真菌的非基于培养的诊断方法。

Non-culture-based diagnostics for opportunistic fungi.

作者信息

Mennink-Kersten Monique A S H, Verweij Paul E

机构信息

Department of Medical Microbiology, Radboud University, Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

出版信息

Infect Dis Clin North Am. 2006 Sep;20(3):711-27, viii. doi: 10.1016/j.idc.2006.06.009.

DOI:10.1016/j.idc.2006.06.009

PMID:16984877

Abstract

The value of the diagnostic markers galactomannan and 1,3-beta-D-glucan for the diagnosis of opportunistic fungal infections is reviewed in this article. Both markers have undergone clinical evaluation, and increasing insight is emerging with respect to the causes of false-negative or false-positive reactivity. These data will help design protocols in which single or multiple markers are used to identify patients who require antifungal therapy.

摘要

本文综述了诊断标志物半乳甘露聚糖和1,3-β-D-葡聚糖在机会性真菌感染诊断中的价值。这两种标志物均已进行临床评估，并且对于假阴性或假阳性反应的原因也有了越来越深入的认识。这些数据将有助于设计使用单一或多种标志物来识别需要抗真菌治疗患者的方案。