Liu Ying, Chen Feng, Zhu Xiaodong, Shen Lisong, Zhang Sean X
Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Pediatrics, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
J Clin Microbiol. 2015 Sep;53(9):3017-20. doi: 10.1128/JCM.00673-15. Epub 2015 Jun 24.
We evaluated a novel plasma (1,3)-β-d-glucan (BDG) detection assay for the diagnosis of candidemia in children. The median BDG levels were 73.4 pg/ml in patients with candidemia and <10 pg/ml in patients without candidemia (P < 0.001). Receiver operating characteristic analysis revealed a cutoff point of 14 pg/ml and an area under the curve of 0.802. At these values, the assay demonstrated 68% sensitivity, 91% specificity, 66% positive predictive value, and 91% negative predictive value. Plasma BDG levels were undetectable in 18 candidemia cases.
我们评估了一种用于诊断儿童念珠菌血症的新型血浆（1,3）-β-D-葡聚糖（BDG）检测方法。念珠菌血症患者的BDG水平中位数为73.4 pg/ml，无念珠菌血症患者的BDG水平<10 pg/ml（P<0.001）。受试者工作特征分析显示，临界值为14 pg/ml，曲线下面积为0.802。在此值时，该检测方法的灵敏度为68%，特异性为91%，阳性预测值为66%，阴性预测值为91%。18例念珠菌血症病例的血浆BDG水平检测不到。
