Stallknecht Bente, Dela Flemming, Helge Jørn Wulff
Department of Medical Physiology, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E394-9. doi: 10.1152/ajpendo.00215.2006. Epub 2006 Sep 19.
Aerobic exercise increases whole body adipose tissue lipolysis, but is lipolysis higher in subcutaneous adipose tissue (SCAT) adjacent to contracting muscles than in SCAT adjacent to resting muscles? Ten healthy, overnight-fasted males performed one-legged knee extension exercise at 25% of maximal workload (W(max)) for 30 min followed by exercise at 55% W(max) for 120 min with the other leg and finally exercised at 85% W(max) for 30 min with the first leg. Subjects rested for 30 min between exercise periods. Femoral SCAT blood flow was estimated from washout of (133)Xe, and lipolysis was calculated from femoral SCAT interstitial and arterial glycerol concentrations and blood flow. In general, blood flow and lipolysis were higher in femoral SCAT adjacent to contracting than adjacent to resting muscle (time 15-30 min; blood flow: 25% W(max) 6.6 +/- 1.0 vs. 3.9 +/- 0.8 ml x 100 g(-1) x min(-1), P < 0.05; 55% W(max) 7.3 +/- 0.6 vs. 5.0 +/- 0.6 ml x 100 g(-1) x min(-1), P < 0.05; 85% W(max) 6.6 +/- 1.3 vs. 5.9 +/- 0.7 ml x 100 g(-1) x min(-1), P > 0.05; lipolysis: 25% W(max) 102 +/- 19 vs. 55 +/- 14 nmol x 100 g(-1) x min(-1), P = 0.06; 55% W(max) 86 +/- 11 vs. 50 +/- 20 nmol x 100 g(-1) x min(-1), P > 0.05; 85% W(max) 88 +/- 31 vs. -9 +/- 25 nmol x 100 g(-1) x min(-1), P < 0.05). In conclusion, blood flow and lipolysis are generally higher in SCAT adjacent to contracting than adjacent to resting muscle irrespective of exercise intensity. Thus specific exercises can induce "spot lipolysis" in adipose tissue.
有氧运动可增加全身脂肪组织的脂解作用，但与静息肌肉相邻的皮下脂肪组织（SCAT）中的脂解作用是否高于与收缩肌肉相邻的SCAT中的脂解作用呢？十名健康的、过夜禁食的男性以最大负荷（W(max)）的25%进行单腿膝关节伸展运动30分钟，然后用另一条腿以55%W(max)进行120分钟运动，最后用第一条腿以85%W(max)进行30分钟运动。受试者在运动时段之间休息30分钟。通过（133）Xe的洗脱估算股部SCAT血流量，并根据股部SCAT间质和动脉甘油浓度及血流量计算脂解作用。总体而言，与收缩肌肉相邻的股部SCAT中的血流量和脂解作用高于与静息肌肉相邻的（运动15 - 30分钟时；血流量：25%W(max)时6.6±1.0对3.9±0.8 ml×100 g(-1)×min(-1)，P<0.05；55%W(max)时7.3±0.6对5.0±0.6 ml×100 g(-1)×min(-1)，P<0.05；85%W(max)时6.6±1.3对5.9±0.7 ml×100 g(-1)×min(-1)，P>0.05；脂解作用：25%W(max)时102±19对55±14 nmol×100 g(-1)×min(-1)，P = 0.06；55%W(max)时86±11对50±20 nmol×100 g(-1)×min(-1)，P>0.05；85%W(max)时88±31对 - 9±25 nmol×100 g(-1)×min(-1)，P<0.05）。总之，无论运动强度如何，与收缩肌肉相邻的SCAT中的血流量和脂解作用通常高于与静息肌肉相邻的。因此，特定运动可诱导脂肪组织中的“局部脂解”。
