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果蝇中类LINE元件I因子转座潜在RNA中间体的鉴定。

Identification of a potential RNA intermediate for transposition of the LINE-like element I factor in Drosophila melanogaster.

作者信息

Chaboissier M C, Busseau I, Prosser J, Finnegan D J, Bucheton A

机构信息

Laboratoire de Génétique, Université Blaise Pascal, Aubière, France.

出版信息

EMBO J. 1990 Nov;9(11):3557-63. doi: 10.1002/j.1460-2075.1990.tb07566.x.

DOI:10.1002/j.1460-2075.1990.tb07566.x
PMID:1698618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC552106/
Abstract

The I factor, a transposable element related to mammalian LINEs, controls the I-R system of hybrid dysgenesis in Drosophila melanogaster. It transposes at high frequency in the germ-line of the female progeny of crosses between females of the reactive class of strains and males of the inducer class. The structure and DNA sequence of the I factor suggest that it transposes by reverse transcription of an RNA intermediate. Northern blot and S1 mapping experiments show that a full-length RNA of the I factor is synthesized specifically in the conditions of which I factors transpose. This RNA has all characteristics of a transposition intermediate. It is only found in the ovaries of dysgenic females suggesting that I factor activity is restricted to this tissue because of regulation at the level of the initiation of transcription or RNA stability.

摘要

I因子是一种与哺乳动物长散在重复序列（LINEs）相关的转座元件，它控制着黑腹果蝇杂交不育的I-R系统。在反应型品系的雌蝇与诱导型品系的雄蝇杂交产生的雌性后代的生殖系中，I因子高频转座。I因子的结构和DNA序列表明它通过RNA中间体的逆转录进行转座。Northern印迹和S1作图实验表明，I因子的全长RNA在I因子发生转座的条件下特异性合成。这种RNA具有转座中间体的所有特征。它仅在不育雌蝇的卵巢中发现，这表明由于转录起始或RNA稳定性水平的调控，I因子的活性仅限于该组织。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/832f75535b65/emboj00238-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/612558e6dda1/emboj00238-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/b206605c54b6/emboj00238-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/fd25ed35bf27/emboj00238-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/832f75535b65/emboj00238-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/612558e6dda1/emboj00238-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/b206605c54b6/emboj00238-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/fd25ed35bf27/emboj00238-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56a5/552106/832f75535b65/emboj00238-0145-a.jpg

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